1-tert-butyloxycarbonyl-(±)-2-[({4-[(2-aminophenyl)carbamoyl]phenyl}methyl)amino]-5-benzyl-4-oxo-4,5-dihydro-1H-imidazole

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Chemical Name:1-tert-butyloxycarbonyl-(±)-2-[({4-[(2-aminophenyl)carbamoyl]phenyl}methyl)amino]-5-benzyl-4-oxo-4,5-dihydro-1H-imidazole
CAS No.:1448350-34-2
Molecular Formula:C₂₉H₃₁N₅O₄
Molecular Weight:513.596
Hs Code.:

Synonyms:1-tert-butyloxycarbonyl-(±)-2-[({4-[(2-aminophenyl)carbamoyl]phenyl}methyl)amino]-5-benzyl-4-oxo-4,5-dihydro-1H-imidazole

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Chemical Property of 1-tert-butyloxycarbonyl-(±)-2-[({4-[(2-aminophenyl)carbamoyl]phenyl}methyl)amino]-5-benzyl-4-oxo-4,5-dihydro-1H-imidazole

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Technology Process of 1-tert-butyloxycarbonyl-(±)-2-[({4-[(2-aminophenyl)carbamoyl]phenyl}methyl)amino]-5-benzyl-4-oxo-4,5-dihydro-1H-imidazole

There total 4 articles about 1-tert-butyloxycarbonyl-(±)-2-[({4-[(2-aminophenyl)carbamoyl]phenyl}methyl)amino]-5-benzyl-4-oxo-4,5-dihydro-1H-imidazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 55.0%

: 1448350-31-9
4-({[(±)-1-(tert-butoxycarbonyl)-5-benzyl-4-oxo-4,5-dihydro-1H-imidazol-2-yl]amino}methyl)benzoic acid

: 95-54-5
1,2-diamino-benzene

: 1448350-34-2
1-tert-butyloxycarbonyl-(±)-2-[({4-[(2-aminophenyl)carbamoyl]phenyl}methyl)amino]-5-benzyl-4-oxo-4,5-dihydro-1H-imidazole

Guidance literature:: 4-({[(±)-1-(tert-butoxycarbonyl)-5-benzyl-4-oxo-4,5-dihydro-1H-imidazol-2-yl]amino}methyl)benzoic acid; With (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; triethylamine; In N,N-dimethyl-formamide; at 20 ℃; for 0.5h; Inert atmosphere;

1,2-diamino-benzene; In N,N-dimethyl-formamide; at 20 ℃; Inert atmosphere;
DOI:10.1021/jm400634n

Reference yield:

: 13734-34-4
N-tert-butoxycarbonyl-L-phenylalanine

: 1448350-34-2
1-tert-butyloxycarbonyl-(±)-2-[({4-[(2-aminophenyl)carbamoyl]phenyl}methyl)amino]-5-benzyl-4-oxo-4,5-dihydro-1H-imidazole

Guidance literature:: Multi-step reaction with 4 steps

1.1: pyridine / acetonitrile / 18 h / 20 °C

2.1: potassium carbonate / acetonitrile / 2.5 h / 20 °C / Inert atmosphere

3.1: ethanol / 18 h / Inert atmosphere; Reflux

4.1: triethylamine; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate / N,N-dimethyl-formamide / 0.5 h / 20 °C / Inert atmosphere

4.2: 20 °C / Inert atmosphere

With pyridine; potassium carbonate; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; triethylamine; In ethanol; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1021/jm400634n

Reference yield:

: 1356003-49-0
tert-butyl (S)-5-benzyl-4-oxo-2-thioxoimidazolidine-1-carboxylate

: 1448350-34-2
1-tert-butyloxycarbonyl-(±)-2-[({4-[(2-aminophenyl)carbamoyl]phenyl}methyl)amino]-5-benzyl-4-oxo-4,5-dihydro-1H-imidazole

Guidance literature:: Multi-step reaction with 3 steps

1.1: potassium carbonate / acetonitrile / 2.5 h / 20 °C / Inert atmosphere

2.1: ethanol / 18 h / Inert atmosphere; Reflux

3.1: triethylamine; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate / N,N-dimethyl-formamide / 0.5 h / 20 °C / Inert atmosphere

3.2: 20 °C / Inert atmosphere

With potassium carbonate; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; triethylamine; In ethanol; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1021/jm400634n