diallyl 4-{[4'-(N,N-bis(2''-hydroxyethyl)amino)phenyl]carbamoyloxymethyl}phenylcarbamoyl-L-glutamate

Base Information

Chemical Name:diallyl 4-{[4'-(N,N-bis(2''-hydroxyethyl)amino)phenyl]carbamoyloxymethyl}phenylcarbamoyl-L-glutamate
CAS No.:528836-43-3
Molecular Formula:C₃₀H₃₈N₄O₉
Molecular Weight:598.653
Hs Code.:

Synonyms:diallyl 4-{[4'-(N,N-bis(2''-hydroxyethyl)amino)phenyl]carbamoyloxymethyl}phenylcarbamoyl-L-glutamate

Suppliers and Price of diallyl 4-{[4'-(N,N-bis(2''-hydroxyethyl)amino)phenyl]carbamoyloxymethyl}phenylcarbamoyl-L-glutamate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of diallyl 4-{[4'-(N,N-bis(2''-hydroxyethyl)amino)phenyl]carbamoyloxymethyl}phenylcarbamoyl-L-glutamate

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of diallyl 4-{[4'-(N,N-bis(2''-hydroxyethyl)amino)phenyl]carbamoyloxymethyl}phenylcarbamoyl-L-glutamate

There total 5 articles about diallyl 4-{[4'-(N,N-bis(2''-hydroxyethyl)amino)phenyl]carbamoyloxymethyl}phenylcarbamoyl-L-glutamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

: 528836-39-7
diallyl 4-{[4'-bis(2''-tert-butyldimethylsilyloxyethyl)aminophenyl]carbamoyloxymethyl}phenylcarbamoyl-L-glutamate

: 528836-43-3
diallyl 4-{[4'-(N,N-bis(2''-hydroxyethyl)amino)phenyl]carbamoyloxymethyl}phenylcarbamoyl-L-glutamate

Guidance literature:: With triethylamine trihydrofluoride; In tetrahydrofuran; at 20 ℃; for 7h;
DOI:10.1021/jm020462i

Reference yield:

: 18226-17-0
N,N-bis(2-hydroxyethyl)-4-nitroaniline

: 528836-43-3
diallyl 4-{[4'-(N,N-bis(2''-hydroxyethyl)amino)phenyl]carbamoyloxymethyl}phenylcarbamoyl-L-glutamate

Guidance literature:: Multi-step reaction with 5 steps

1: 89 percent / imidazole / dimethylformamide / 20 h / 20 °C

2: 95 percent / H₂ / Pd/C / tetrahydrofuran / 6 h

3: Et₃N / CH₂Cl₂ / 0.25 h

4: 3.10 g / dibutyltin laurate / CH₂Cl₂ / 20 h / 20 °C

5: 97 percent / triethylamine trihydrofluoride / tetrahydrofuran / 7 h / 20 °C

With 1H-imidazole; dibutyltin(II) dilaurate; triethylamine trihydrofluoride; hydrogen; triethylamine; palladium on activated charcoal; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm020462i

Reference yield:

: 304015-61-0
N,N-bis(2-{[tert-butyldimethylsilyl]oxy}ethyl)-4-nitroaniline

: 528836-43-3
diallyl 4-{[4'-(N,N-bis(2''-hydroxyethyl)amino)phenyl]carbamoyloxymethyl}phenylcarbamoyl-L-glutamate

Guidance literature:: Multi-step reaction with 4 steps

1: 95 percent / H₂ / Pd/C / tetrahydrofuran / 6 h

2: Et₃N / CH₂Cl₂ / 0.25 h

3: 3.10 g / dibutyltin laurate / CH₂Cl₂ / 20 h / 20 °C

4: 97 percent / triethylamine trihydrofluoride / tetrahydrofuran / 7 h / 20 °C

With dibutyltin(II) dilaurate; triethylamine trihydrofluoride; hydrogen; triethylamine; palladium on activated charcoal; In tetrahydrofuran; dichloromethane;
DOI:10.1021/jm020462i