4-N-(3-(4-(((benzyl(5-((2H-tetrahydropyran-2-yloxy)pentyl)carbamoyl)oxy)methyl)phenyl)propionyl)sulfamoyl)benzoic acid

Base Information

Chemical Name:4-N-(3-(4-(((benzyl(5-((2H-tetrahydropyran-2-yloxy)pentyl)carbamoyl)oxy)methyl)phenyl)propionyl)sulfamoyl)benzoic acid
CAS No.:1426441-04-4
Molecular Formula:C₃₅H₄₂N₂O₉S
Molecular Weight:666.792
Hs Code.:

Synonyms:4-N-(3-(4-(((benzyl(5-((2H-tetrahydropyran-2-yloxy)pentyl)carbamoyl)oxy)methyl)phenyl)propionyl)sulfamoyl)benzoic acid

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Chemical Property of 4-N-(3-(4-(((benzyl(5-((2H-tetrahydropyran-2-yloxy)pentyl)carbamoyl)oxy)methyl)phenyl)propionyl)sulfamoyl)benzoic acid

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Technology Process of 4-N-(3-(4-(((benzyl(5-((2H-tetrahydropyran-2-yloxy)pentyl)carbamoyl)oxy)methyl)phenyl)propionyl)sulfamoyl)benzoic acid

There total 3 articles about 4-N-(3-(4-(((benzyl(5-((2H-tetrahydropyran-2-yloxy)pentyl)carbamoyl)oxy)methyl)phenyl)propionyl)sulfamoyl)benzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

: 138-41-0
4-(aminosulfonyl)-benzoic acid

: 1426441-03-3
3-(4-((benzyl(5-O-(tetrahydropyranyloxy)pentyl)carbamoyloxy)methyl)phenyl)propanoic acid

: 1426441-04-4
4-N-(3-(4-(((benzyl(5-((2H-tetrahydropyran-2-yloxy)pentyl)carbamoyl)oxy)methyl)phenyl)propionyl)sulfamoyl)benzoic acid

Guidance literature:: 3-(4-((benzyl(5-O-(tetrahydropyranyloxy)pentyl)carbamoyloxy)methyl)phenyl)propanoic acid; With dicyclohexyl-carbodiimide; In dichloromethane; at 20 ℃; for 3h; Inert atmosphere;

4-(aminosulfonyl)-benzoic acid; In dichloromethane; N,N-dimethyl-formamide; at 20 ℃; Inert atmosphere;
DOI:10.3762/bjoc.8.232

Reference yield:

: 110-87-2
3,4-dihydro-2H-pyran

: 1426441-04-4
4-N-(3-(4-(((benzyl(5-((2H-tetrahydropyran-2-yloxy)pentyl)carbamoyl)oxy)methyl)phenyl)propionyl)sulfamoyl)benzoic acid

Guidance literature:: Multi-step reaction with 3 steps

1.1: pyridinium p-toluenesulfonate / dichloromethane / Inert atmosphere

2.1: lithium hydroxide monohydrate / tetrahydrofuran; water / 2 h / Reflux; Inert atmosphere

2.2: IR-120 (H+) / pH 5 - 6

3.1: dicyclohexyl-carbodiimide / dichloromethane / 3 h / 20 °C / Inert atmosphere

3.2: 20 °C / Inert atmosphere

With lithium hydroxide monohydrate; pyridinium p-toluenesulfonate; dicyclohexyl-carbodiimide; In tetrahydrofuran; dichloromethane; water;
DOI:10.3762/bjoc.8.232

Reference yield:

: 1426441-02-2
methyl 3-(4-((benzyl(5-O-(tetrahydropyranyloxy)pentyl)carbamoyloxy)methyl)phenyl)propanoate

: 1426441-04-4
4-N-(3-(4-(((benzyl(5-((2H-tetrahydropyran-2-yloxy)pentyl)carbamoyl)oxy)methyl)phenyl)propionyl)sulfamoyl)benzoic acid

Guidance literature:: Multi-step reaction with 2 steps

1.1: lithium hydroxide monohydrate / tetrahydrofuran; water / 2 h / Reflux; Inert atmosphere

1.2: IR-120 (H+) / pH 5 - 6

2.1: dicyclohexyl-carbodiimide / dichloromethane / 3 h / 20 °C / Inert atmosphere

2.2: 20 °C / Inert atmosphere

With lithium hydroxide monohydrate; dicyclohexyl-carbodiimide; In tetrahydrofuran; dichloromethane; water;
DOI:10.3762/bjoc.8.232