benzyl 4-(N-(3-(4-((benzyl(5-hydroxypentyl)carbamoyloxy)methyl)phenyl)propionyl)sulfamoyl)benzoate

Base Information

Chemical Name:benzyl 4-(N-(3-(4-((benzyl(5-hydroxypentyl)carbamoyloxy)methyl)phenyl)propionyl)sulfamoyl)benzoate
CAS No.:1426441-05-5
Molecular Formula:C₃₇H₄₀N₂O₈S
Molecular Weight:672.799
Hs Code.:

Synonyms:benzyl 4-(N-(3-(4-((benzyl(5-hydroxypentyl)carbamoyloxy)methyl)phenyl)propionyl)sulfamoyl)benzoate

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Chemical Property of benzyl 4-(N-(3-(4-((benzyl(5-hydroxypentyl)carbamoyloxy)methyl)phenyl)propionyl)sulfamoyl)benzoate

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Technology Process of benzyl 4-(N-(3-(4-((benzyl(5-hydroxypentyl)carbamoyloxy)methyl)phenyl)propionyl)sulfamoyl)benzoate

There total 3 articles about benzyl 4-(N-(3-(4-((benzyl(5-hydroxypentyl)carbamoyloxy)methyl)phenyl)propionyl)sulfamoyl)benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 55.0%

: 1426441-04-4
4-N-(3-(4-(((benzyl(5-((2H-tetrahydropyran-2-yloxy)pentyl)carbamoyl)oxy)methyl)phenyl)propionyl)sulfamoyl)benzoic acid

: 100-51-6,185532-71-2
benzyl alcohol

: 1426441-05-5
benzyl 4-(N-(3-(4-((benzyl(5-hydroxypentyl)carbamoyloxy)methyl)phenyl)propionyl)sulfamoyl)benzoate

Guidance literature:: 4-N-(3-(4-(((benzyl(5-((2H-tetrahydropyran-2-yloxy)pentyl)carbamoyl)oxy)methyl)phenyl)propionyl)sulfamoyl)benzoic acid; benzyl alcohol; With dmap; dicyclohexyl-carbodiimide; In dichloromethane; at 20 ℃; for 8h; Inert atmosphere;

With toluene-4-sulfonic acid; In methanol; for 6h; Inert atmosphere;
DOI:10.3762/bjoc.8.232

Reference yield:

: 1426441-02-2
methyl 3-(4-((benzyl(5-O-(tetrahydropyranyloxy)pentyl)carbamoyloxy)methyl)phenyl)propanoate

: 1426441-05-5
benzyl 4-(N-(3-(4-((benzyl(5-hydroxypentyl)carbamoyloxy)methyl)phenyl)propionyl)sulfamoyl)benzoate

Guidance literature:: Multi-step reaction with 3 steps

1.1: lithium hydroxide monohydrate / tetrahydrofuran; water / 2 h / Reflux; Inert atmosphere

1.2: IR-120 (H+) / pH 5 - 6

2.1: dicyclohexyl-carbodiimide / dichloromethane / 3 h / 20 °C / Inert atmosphere

2.2: 20 °C / Inert atmosphere

3.1: dicyclohexyl-carbodiimide; dmap / dichloromethane / 8 h / 20 °C / Inert atmosphere

3.2: 6 h / Inert atmosphere

With dmap; lithium hydroxide monohydrate; dicyclohexyl-carbodiimide; In tetrahydrofuran; dichloromethane; water;
DOI:10.3762/bjoc.8.232

Reference yield:

: 138-41-0
4-(aminosulfonyl)-benzoic acid

: 1426441-03-3
3-(4-((benzyl(5-O-(tetrahydropyranyloxy)pentyl)carbamoyloxy)methyl)phenyl)propanoic acid

: 1426441-05-5
benzyl 4-(N-(3-(4-((benzyl(5-hydroxypentyl)carbamoyloxy)methyl)phenyl)propionyl)sulfamoyl)benzoate

Guidance literature:: Multi-step reaction with 2 steps

1.1: dicyclohexyl-carbodiimide / dichloromethane / 3 h / 20 °C / Inert atmosphere

1.2: 20 °C / Inert atmosphere

2.1: dicyclohexyl-carbodiimide; dmap / dichloromethane / 8 h / 20 °C / Inert atmosphere

2.2: 6 h / Inert atmosphere

With dmap; dicyclohexyl-carbodiimide; In dichloromethane;
DOI:10.3762/bjoc.8.232