7-[2',5'-dideoxy-5'-(4-monomethoxytritylamino)-3'-O-succinyl-β-D-erythro-pentofuranosyl]-2-isobutyrylamino-3,7-dihydro-4H-pyrrolo[2,3-d]pyrimidin-4-one

Base Information

Chemical Name:7-[2',5'-dideoxy-5'-(4-monomethoxytritylamino)-3'-O-succinyl-β-D-erythro-pentofuranosyl]-2-isobutyrylamino-3,7-dihydro-4H-pyrrolo[2,3-d]pyrimidin-4-one
CAS No.:915286-92-9
Molecular Formula:C₃₉H₄₁N₅O₈
Molecular Weight:707.783
Hs Code.:

7-[2',5'-dideoxy-5'-(4-monomethoxytritylamino)-3'-O-succinyl-β-D-erythro-pentofuranosyl]-2-isobutyrylamino-3,7-dihydro-4H-pyrrolo[2,3-d]pyrimidin-4-one

Synonyms:7-[2',5'-dideoxy-5'-(4-monomethoxytritylamino)-3'-O-succinyl-β-D-erythro-pentofuranosyl]-2-isobutyrylamino-3,7-dihydro-4H-pyrrolo[2,3-d]pyrimidin-4-one

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Chemical Property of 7-[2',5'-dideoxy-5'-(4-monomethoxytritylamino)-3'-O-succinyl-β-D-erythro-pentofuranosyl]-2-isobutyrylamino-3,7-dihydro-4H-pyrrolo[2,3-d]pyrimidin-4-one

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Technology Process of 7-[2',5'-dideoxy-5'-(4-monomethoxytritylamino)-3'-O-succinyl-β-D-erythro-pentofuranosyl]-2-isobutyrylamino-3,7-dihydro-4H-pyrrolo[2,3-d]pyrimidin-4-one

There total 10 articles about 7-[2',5'-dideoxy-5'-(4-monomethoxytritylamino)-3'-O-succinyl-β-D-erythro-pentofuranosyl]-2-isobutyrylamino-3,7-dihydro-4H-pyrrolo[2,3-d]pyrimidin-4-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 915286-91-8
7-[2',5'-dideoxy-5'-(4-monomethoxytritylamino)-β-D-erythro-pentofuranosyl]-2-isobutyrylamino-3,7-dihydro-4H-pyrrolo[2,3-d]pyrimidin-4-one

: 108-30-5
succinic acid anhydride

: 915286-92-9
7-[2',5'-dideoxy-5'-(4-monomethoxytritylamino)-3'-O-succinyl-β-D-erythro-pentofuranosyl]-2-isobutyrylamino-3,7-dihydro-4H-pyrrolo[2,3-d]pyrimidin-4-one

Guidance literature:: With triethylamine; In dichloromethane; for 3h;
DOI:10.1016/j.bmc.2006.05.074

Reference yield:

: 121150-07-0
7-(2'-deoxy-β-D-erythro-pentofuranosyl)-2-isobutyrylamino-4-methoxy-7H-pyrrolo[2,3-d]pyrimidine

: 915286-92-9
7-[2',5'-dideoxy-5'-(4-monomethoxytritylamino)-3'-O-succinyl-β-D-erythro-pentofuranosyl]-2-isobutyrylamino-3,7-dihydro-4H-pyrrolo[2,3-d]pyrimidin-4-one

Guidance literature:: Multi-step reaction with 6 steps

1: 73 percent / pyridine / 14 h / 20 °C

2: 81 percent / lithium azide / dimethylformamide / 2 h / 90 °C

3: 93 percent / hydrogen / palladium on carbon / ethanol / 5 h / 20 °C / 2327.17 Torr

4: 73 percent / pyridine / 18 h / 20 °C

5: 85 percent / sodium thiocresolate / dimethylformamide / 1 h / 90 °C

6: 90 percent / triethylamine / CH₂Cl₂ / 3 h

With pyridine; lithium azide; sodium 4-mercaptobenzoate; hydrogen; triethylamine; palladium on activated charcoal; In ethanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2006.05.074

Reference yield:

: 915286-88-3
7-[5'-azido-2',5'-dideoxy-β-D-erythro-pentofuranosyl]-2-isobutyrylamino-4-methoxy-7H-pyrrolo[2,3-d]pyrimidine

: 915286-92-9
7-[2',5'-dideoxy-5'-(4-monomethoxytritylamino)-3'-O-succinyl-β-D-erythro-pentofuranosyl]-2-isobutyrylamino-3,7-dihydro-4H-pyrrolo[2,3-d]pyrimidin-4-one

Guidance literature:: Multi-step reaction with 4 steps

1: 93 percent / hydrogen / palladium on carbon / ethanol / 5 h / 20 °C / 2327.17 Torr

2: 73 percent / pyridine / 18 h / 20 °C

3: 85 percent / sodium thiocresolate / dimethylformamide / 1 h / 90 °C

4: 90 percent / triethylamine / CH₂Cl₂ / 3 h

With pyridine; sodium 4-mercaptobenzoate; hydrogen; triethylamine; palladium on activated charcoal; In ethanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2006.05.074