3-[3,5-bis-acetoxymethyl-4-(tert-butyl-dimethyl-silanyloxy)-phenyl]-acrylic acid 2,5-dioxo-pyrrolidin-1-yl ester

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Chemical Name:3-[3,5-bis-acetoxymethyl-4-(tert-butyl-dimethyl-silanyloxy)-phenyl]-acrylic acid 2,5-dioxo-pyrrolidin-1-yl ester
CAS No.:692729-63-8
Molecular Formula:C₂₅H₃₃NO₉Si
Molecular Weight:519.624
Hs Code.:

3-[3,5-bis-acetoxymethyl-4-(<i>tert</i>-butyl-dimethyl-silanyloxy)-phenyl]-acrylic acid 2,5-dioxo-pyrrolidin-1-yl ester

Synonyms:3-[3,5-bis-acetoxymethyl-4-(tert-butyl-dimethyl-silanyloxy)-phenyl]-acrylic acid 2,5-dioxo-pyrrolidin-1-yl ester

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Chemical Property of 3-[3,5-bis-acetoxymethyl-4-(tert-butyl-dimethyl-silanyloxy)-phenyl]-acrylic acid 2,5-dioxo-pyrrolidin-1-yl ester

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Technology Process of 3-[3,5-bis-acetoxymethyl-4-(tert-butyl-dimethyl-silanyloxy)-phenyl]-acrylic acid 2,5-dioxo-pyrrolidin-1-yl ester

There total 5 articles about 3-[3,5-bis-acetoxymethyl-4-(tert-butyl-dimethyl-silanyloxy)-phenyl]-acrylic acid 2,5-dioxo-pyrrolidin-1-yl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 64.0%

: 6066-82-6
1-hydroxy-pyrrolidine-2,5-dione

: 692729-62-7
3-[3,5-bis-acetoxymethyl-4-(tert-butyl-dimethyl-silanyloxy)-phenyl]-acrylic acid

: 692729-63-8
3-[3,5-bis-acetoxymethyl-4-(tert-butyl-dimethyl-silanyloxy)-phenyl]-acrylic acid 2,5-dioxo-pyrrolidin-1-yl ester

Guidance literature:: With N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; In dichloromethane; at 20 ℃; for 12h;
DOI:10.1016/j.tetlet.2004.02.070

Reference yield:

: 247226-70-6
2,6-bis(morpholinomethyl)phenol

: 692729-63-8
3-[3,5-bis-acetoxymethyl-4-(tert-butyl-dimethyl-silanyloxy)-phenyl]-acrylic acid 2,5-dioxo-pyrrolidin-1-yl ester

Guidance literature:: Multi-step reaction with 7 steps

1.1: NaI; chloramine-T / dimethylsulfoxide / 50 °C

2.1: 69 percent / acetic acid

3.1: 84 percent / (o-CH₃C₆H₄)3P; Et₃N / Pd(OAc(2 / toluene / 24 h / 100 °C

4.1: H₂SO₄ / tetrahydrofuran; H₂O / 3.5 h / 80 °C

4.2: 71 percent / LiOH / H₂O / 2 h / 20 °C

5.1: 39 percent / imidazole / dimethylformamide / 48 h

6.1: 43 percent / FeCl₃ / 0 °C

7.1: 64 percent / EDC / CH₂Cl₂ / 12 h / 20 °C

With 1H-imidazole; sulfuric acid; chloroamine-T; iron(III) chloride; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; triethylamine; tris-(o-tolyl)phosphine; sodium iodide; palladium diacetate; In tetrahydrofuran; dichloromethane; water; acetic acid; dimethyl sulfoxide; N,N-dimethyl-formamide; toluene; 3.1: Heck reaction;
DOI:10.1016/j.tetlet.2004.02.070

Reference yield:

: 205877-24-3
2,6-bis(morpholinomethyl)-4-iodophenol

: 692729-63-8
3-[3,5-bis-acetoxymethyl-4-(tert-butyl-dimethyl-silanyloxy)-phenyl]-acrylic acid 2,5-dioxo-pyrrolidin-1-yl ester

Guidance literature:: Multi-step reaction with 6 steps

1.1: 69 percent / acetic acid

2.1: 84 percent / (o-CH₃C₆H₄)3P; Et₃N / Pd(OAc(2 / toluene / 24 h / 100 °C

3.1: H₂SO₄ / tetrahydrofuran; H₂O / 3.5 h / 80 °C

3.2: 71 percent / LiOH / H₂O / 2 h / 20 °C

4.1: 39 percent / imidazole / dimethylformamide / 48 h

5.1: 43 percent / FeCl₃ / 0 °C

6.1: 64 percent / EDC / CH₂Cl₂ / 12 h / 20 °C

With 1H-imidazole; sulfuric acid; iron(III) chloride; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; triethylamine; tris-(o-tolyl)phosphine; palladium diacetate; In tetrahydrofuran; dichloromethane; water; acetic acid; N,N-dimethyl-formamide; toluene; 2.1: Heck reaction;
DOI:10.1016/j.tetlet.2004.02.070