(E)-3-{3-[5-methyl-2-(4-trifluoromethylphenyl)oxazol-4-ylmethoxy]phenyl}but-2-enylurea

Base Information

Chemical Name:(E)-3-{3-[5-methyl-2-(4-trifluoromethylphenyl)oxazol-4-ylmethoxy]phenyl}but-2-enylurea
CAS No.:180084-78-0
Molecular Formula:C₂₃H₂₂F₃N₃O₃
Molecular Weight:445.441
Hs Code.:

Synonyms:(E)-3-{3-[5-methyl-2-(4-trifluoromethylphenyl)oxazol-4-ylmethoxy]phenyl}but-2-enylurea

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (E)-3-{3-[5-methyl-2-(4-trifluoromethylphenyl)oxazol-4-ylmethoxy]phenyl}but-2-enylurea

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Technology Process of (E)-3-{3-[5-methyl-2-(4-trifluoromethylphenyl)oxazol-4-ylmethoxy]phenyl}but-2-enylurea

There total 9 articles about (E)-3-{3-[5-methyl-2-(4-trifluoromethylphenyl)oxazol-4-ylmethoxy]phenyl}but-2-enylurea which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 55.0%

: 1118-02-1
trimethylsilyl isocyanate

: 180084-77-9
(E)-3-{3-[5-Methyl-2-(4-trifluoromethyl-phenyl)-oxazol-4-ylmethoxy]-phenyl}-but-2-enylamine

: 180084-78-0
(E)-3-{3-[5-methyl-2-(4-trifluoromethylphenyl)oxazol-4-ylmethoxy]phenyl}but-2-enylurea

Guidance literature:: In 1,4-dioxane; for 18h;
DOI:10.1021/jm990476x

Reference yield:

: 455-19-6
4-Trifluoromethylbenzaldehyde

: 180084-78-0
(E)-3-{3-[5-methyl-2-(4-trifluoromethylphenyl)oxazol-4-ylmethoxy]phenyl}but-2-enylurea

Guidance literature:: Multi-step reaction with 9 steps

1.1: 65 percent / HCl gas / ethyl acetate / 3 h / 5 °C

2.1: 30 percent / POCl₃ / CHCl₃ / 2.5 h / Heating

3.1: 82 percent / K₂CO₃ / dimethylformamide / 10 h / 65 °C

4.1: NaH / toluene / 1 h

4.2: 81 percent / toluene; tetrahydrofuran / 48 h

5.1: 95 percent / DIBAL / diethyl ether / 0.5 h / -78 °C

6.1: 35 percent / PCl₅; CaCO₃ / diethyl ether / 0.5 h / 0 °C

7.1: NaN₃ / dimethylformamide / 18 h / 0 °C

8.1: LiAlH₄ / tetrahydrofuran / 0.33 h

9.1: 55 percent / dioxane / 18 h

With hydrogenchloride; lithium aluminium tetrahydride; sodium azide; phosphorus pentachloride; sodium hydride; diisobutylaluminium hydride; potassium carbonate; calcium carbonate; trichlorophosphate; In tetrahydrofuran; 1,4-dioxane; diethyl ether; chloroform; ethyl acetate; N,N-dimethyl-formamide; toluene; 1.1: Condensation / 2.1: Chlorination / 3.1: Alkylation / 4.1: Metallation / 4.2: Condensation / 5.1: Reduction / 6.1: Chlorination / 7.1: Substitution / 8.1: Reduction / 9.1: Condensation;
DOI:10.1021/jm990476x

Reference yield:

: 174258-39-0
4-(chloromethyl)-5-methyl-2-[4-(trifluoromethyl)phenyl]-1,3-oxazole

: 180084-78-0
(E)-3-{3-[5-methyl-2-(4-trifluoromethylphenyl)oxazol-4-ylmethoxy]phenyl}but-2-enylurea

Guidance literature:: Multi-step reaction with 7 steps

1.1: 82 percent / K₂CO₃ / dimethylformamide / 10 h / 65 °C

2.1: NaH / toluene / 1 h

2.2: 81 percent / toluene; tetrahydrofuran / 48 h

3.1: 95 percent / DIBAL / diethyl ether / 0.5 h / -78 °C

4.1: 35 percent / PCl₅; CaCO₃ / diethyl ether / 0.5 h / 0 °C

5.1: NaN₃ / dimethylformamide / 18 h / 0 °C

6.1: LiAlH₄ / tetrahydrofuran / 0.33 h

7.1: 55 percent / dioxane / 18 h

With lithium aluminium tetrahydride; sodium azide; phosphorus pentachloride; sodium hydride; diisobutylaluminium hydride; potassium carbonate; calcium carbonate; In tetrahydrofuran; 1,4-dioxane; diethyl ether; N,N-dimethyl-formamide; toluene; 1.1: Alkylation / 2.1: Metallation / 2.2: Condensation / 3.1: Reduction / 4.1: Chlorination / 5.1: Substitution / 6.1: Reduction / 7.1: Condensation;
DOI:10.1021/jm990476x