3-(4-benzyloxyphenyl)-(S)-2-ethoxy-N-(2-hydroxy-(R)-1-phenylethyl)propanoic amide

Base Information

Chemical Name:3-(4-benzyloxyphenyl)-(S)-2-ethoxy-N-(2-hydroxy-(R)-1-phenylethyl)propanoic amide
CAS No.:251454-48-5
Molecular Formula:C₂₆H₂₉NO₄
Molecular Weight:419.521
Hs Code.:

Synonyms:3-(4-benzyloxyphenyl)-(S)-2-ethoxy-N-(2-hydroxy-(R)-1-phenylethyl)propanoic amide

Suppliers and Price of 3-(4-benzyloxyphenyl)-(S)-2-ethoxy-N-(2-hydroxy-(R)-1-phenylethyl)propanoic amide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 3-(4-benzyloxyphenyl)-(S)-2-ethoxy-N-(2-hydroxy-(R)-1-phenylethyl)propanoic amide

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 3-(4-benzyloxyphenyl)-(S)-2-ethoxy-N-(2-hydroxy-(R)-1-phenylethyl)propanoic amide

There total 8 articles about 3-(4-benzyloxyphenyl)-(S)-2-ethoxy-N-(2-hydroxy-(R)-1-phenylethyl)propanoic amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 37.0%

: 251454-47-4
3-[4-(Benzyloxy)phenyl]-2-ethoxypropanoic acid

: 56613-80-0
D-2-phenylglycinol

: 251454-48-5
3-(4-benzyloxyphenyl)-(S)-2-ethoxy-N-(2-hydroxy-(R)-1-phenylethyl)propanoic amide

: 3-(4-benzyloxyphenyl)-(R)-2-ethoxy-N-(2-hydroxy-(R)-1-phenylethyl)propanoic amide

Guidance literature:: With benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃;

Reference yield: 31.0%

: 251454-47-4
3-[4-(Benzyloxy)phenyl]-2-ethoxypropanoic acid

: 142-82-5
n-heptane

: 122-98-5
2-Anilinoethanol

: 251454-48-5
3-(4-benzyloxyphenyl)-(S)-2-ethoxy-N-(2-hydroxy-(R)-1-phenylethyl)propanoic amide

Guidance literature:: With benzotriazol-1-ol; 1,2-dichloro-ethane; N-ethyl-N,N-diisopropylamine; In dichloromethane; water; ethyl acetate;

Reference yield:

: 4397-53-9
p-benzyloxybenzaldehyde

: 251454-48-5
3-(4-benzyloxyphenyl)-(S)-2-ethoxy-N-(2-hydroxy-(R)-1-phenylethyl)propanoic amide

Guidance literature:: Multi-step reaction with 5 steps

1: 93 percent / tetramethylguanidine / CH₂Cl₂ / 0 - 20 °C

2: 95 percent / H₂ / Pd/C / methanol

3: 75 percent / K₂CO₃ / dimethylformamide / 120 °C

4: 94 percent / aq. LiOH / methanol; tetrahydrofuran

5: 30 percent / EDCI; HOBT; DIEA / CH₂Cl₂ / 0 - 20 °C

With lithium hydroxide; 1,1,3,3-tetramethylguanidine; hydrogen; potassium carbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; palladium on activated charcoal; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide; 1: Wittig olefination;
DOI:10.1016/j.bmcl.2007.04.057