4-((4-(bromomethyl)benzyl)oxy)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione

Base Information

Chemical Name:4-((4-(bromomethyl)benzyl)oxy)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione
CAS No.:1323408-40-7
Molecular Formula:C₂₁H₁₇BrN₂O₅
Molecular Weight:457.28
Hs Code.:

Synonyms:4-((4-(bromomethyl)benzyl)oxy)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione

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Chemical Property of 4-((4-(bromomethyl)benzyl)oxy)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione

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Technology Process of 4-((4-(bromomethyl)benzyl)oxy)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione

There total 9 articles about 4-((4-(bromomethyl)benzyl)oxy)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 1323405-38-4
2-(2,6-dioxo-3-piperidyl)-4-[[4-(hydroxymethyl)phenyl]methoxy]isoindoline-1,3-dione

: 1323408-40-7
4-((4-(bromomethyl)benzyl)oxy)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione

Guidance literature:: 2-(2,6-dioxo-3-piperidyl)-4-[[4-(hydroxymethyl)phenyl]methoxy]isoindoline-1,3-dione; With phosphorus tribromide; In dichloromethane; acetonitrile; at 0 - 20 ℃; for 20.08h; Inert atmosphere;

With tetrabutylammomium bromide; sodium bromide; In dichloromethane; acetonitrile; at 20 ℃; for 14h; Inert atmosphere;
DOI:10.1021/acs.jmedchem.9b01928

Reference yield:

: 24666-56-6,2686-86-4
rac-α-aminoglutarimide hydrochloride

: 1323408-40-7
4-((4-(bromomethyl)benzyl)oxy)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium acetate / acetic acid / 2 h / 100 °C / Inert atmosphere

2.1: potassium carbonate / N,N-dimethyl-formamide / 3 h / 20 °C / Inert atmosphere

3.1: sulfuric acid / tetrahydrofuran / 0.5 h / 20 °C / Inert atmosphere

4.1: phosphorus tribromide / dichloromethane; acetonitrile / 20.08 h / 0 - 20 °C / Inert atmosphere

4.2: 14 h / 20 °C / Inert atmosphere

With sulfuric acid; sodium acetate; phosphorus tribromide; potassium carbonate; In tetrahydrofuran; dichloromethane; acetic acid; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1021/acs.jmedchem.9b01928

Reference yield:

: 37418-88-5
3-hydroxyphthalic anhydride

: 1323408-40-7
4-((4-(bromomethyl)benzyl)oxy)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium acetate / acetic acid / 2 h / 100 °C / Inert atmosphere

2.1: potassium carbonate / N,N-dimethyl-formamide / 3 h / 20 °C / Inert atmosphere

3.1: sulfuric acid / tetrahydrofuran / 0.5 h / 20 °C / Inert atmosphere

4.1: phosphorus tribromide / dichloromethane; acetonitrile / 20.08 h / 0 - 20 °C / Inert atmosphere

4.2: 14 h / 20 °C / Inert atmosphere

With sulfuric acid; sodium acetate; phosphorus tribromide; potassium carbonate; In tetrahydrofuran; dichloromethane; acetic acid; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1021/acs.jmedchem.9b01928