4-Hydroxy thalidomide

Base Information Edit

Chemical Name:4-Hydroxy thalidomide
CAS No.:5054-59-1
Molecular Formula:C13H10N2O5
Molecular Weight:274.233
Hs Code.:2933998090
European Community (EC) Number:826-734-9
UNII:J344NHC6VB
ChEMBL ID:CHEMBL2324714
Nikkaji Number:J974.097J
Wikidata:Q27281110
Mol file:5054-59-1.mol

Synonyms:5054-59-1;4-Hydroxy thalidomide;E3 ligase Ligand 2;2-(2,6-dioxopiperidin-3-yl)-4-hydroxyisoindoline-1,3-dione;4-Hydroxythalidomide;Thalidomide-4-OH;2-(2,6-dioxopiperidin-3-yl)-4-hydroxyisoindole-1,3-dione;2-(2,6-Dioxo-3-piperidinyl)-4-hydroxyisoindoline-1,3-dione;4-Hydroxy-thalidomide;4-Hydroxy thalidomide, (+/-)-;E3 ligase Ligand 2 (Thalidomide-OH);J344NHC6VB;C13H10N2O5;MFCD03699892;Phthalimide, N-(2,6-dioxo-3-piperidyl)-3-hydroxy-;1H-Isoindole-1,3(2H)-dione, 2-(2,6-dioxo-3-piperidinyl)-4-hydroxy-;2-(2,6-dioxopiperidin-3-yl)-4-hydroxy-2,3-dihydro-1H-isoindole-1,3-dione;UNII-J344NHC6VB;YSZC396;SCHEMBL1097854;CHEMBL2324714;XMPJICVFSDYOEG-UHFFFAOYSA-N;BDBM511638;AMY27835;BCP20021;EX-A3861;Cereblon ligand 2;US11059801, Compound D-1;AC6253;US11059801, Compound D-57;AKOS037630830;CS-7732;BP-24437;SY233142;HY-103596;EN300-6472923;A903633;Q27281110;Z2508933059;2-(2,6-Dioxo-piperidin-3-yl)-4-hydroxy-isoindole-1,3-dione;2-(2,6-dioxo-piperidine-3-yl)-4-hydroxy-isoindole-1,3-dione;4-hydroxy-2-(2,6-dioxo(3-piperidyl))isoindoline-1,3-dione

Suppliers and Price of 4-Hydroxy thalidomide

Supply Marketing:Edit

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

DC Chemicals
E3LigaseLigand2 >98%
1 g
$ 700.00

DC Chemicals
E3LigaseLigand2 >98%
5 g
$ 1800.00

CSNpharm
E3ligaseLigand2
1g
$ 1020.00

CSNpharm
E3ligaseLigand2
100mg
$ 213.00

Chemenu
2-(2,6-dioxopiperidin-3-yl)-4-hydroxyisoindole-1,3-dione 95%+
25g
$ 1280.00

BroadPharm
4-Hydroxy-thalidomide 98%
5 G
$ 330.00

Biorbyt Ltd
E3 Ligase Ligand 2 >98%
10 g
$ 4173.50

Biorbyt Ltd
E3 Ligase Ligand 2 >98%
5 g
$ 2691.10

Biorbyt Ltd
E3 Ligase Ligand 2 >98%
1 g
$ 1060.80

ApexBio Technology
Thalidomide-4-OH
500mg
$ 250.00

Total 41 raw suppliers

Chemical Property of 4-Hydroxy thalidomide Edit

Chemical Property:

Melting Point:273-275 °C
Boiling Point:568.3±45.0 °C(Predicted)
PKA:6.82±0.20(Predicted)
PSA：103.78000
Density:1.611±0.06 g/cm3(Predicted)
LogP:0.06010
Storage Temp.:under inert gas (nitrogen or Argon) at 2-8°C
XLogP3:0.5
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:1
Exact Mass:274.05897142
Heavy Atom Count:20
Complexity:503

Purity/Quality:

98% ^*data from raw suppliers

E3LigaseLigand2 >98% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:C1CC(=O)NC(=O)C1N2C(=O)C3=C(C2=O)C(=CC=C3)O
Description 4-Hydroxy-thalidomide is the Thalidomide-based Cereblon ligand used in the recruitment of CRBN protein. It can be connected to the ligand for protein by a linker to form PROTACs.
Uses 2-(2,6-Dioxopiperidin-3-yl)-4-hydroxyisoindoline-1,3-dione is an intermediate for the synthesis of dTAG-13 (D710020), which is a degradation tag which was tested for its efficiency at depleting FKBP12F36V -MELK(sg3R) and was found to have significantly degraded FKBP12F36V -MELK(sg3R) within 4 hours.Used in the study of cancer research.

Technology Process of 4-Hydroxy thalidomide

There total 2 articles about 4-Hydroxy thalidomide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%