2-phenyl-5-trifluoromethyloxazole-4-carboxylic acid (1',2',3',4',5',6'-hexahydro-(2,4'-bipyridin-5-yl)amide)

Base Information

Chemical Name:2-phenyl-5-trifluoromethyloxazole-4-carboxylic acid (1',2',3',4',5',6'-hexahydro-(2,4'-bipyridin-5-yl)amide)
CAS No.:1085841-79-7
Molecular Formula:C₂₁H₁₉F₃N₄O₂
Molecular Weight:416.403
Hs Code.:

Synonyms:2-phenyl-5-trifluoromethyloxazole-4-carboxylic acid (1',2',3',4',5',6'-hexahydro-(2,4'-bipyridin-5-yl)amide)

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Chemical Property of 2-phenyl-5-trifluoromethyloxazole-4-carboxylic acid (1',2',3',4',5',6'-hexahydro-(2,4'-bipyridin-5-yl)amide)

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Technology Process of 2-phenyl-5-trifluoromethyloxazole-4-carboxylic acid (1',2',3',4',5',6'-hexahydro-(2,4'-bipyridin-5-yl)amide)

There total 5 articles about 2-phenyl-5-trifluoromethyloxazole-4-carboxylic acid (1',2',3',4',5',6'-hexahydro-(2,4'-bipyridin-5-yl)amide) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.5%

: 1085843-37-3
5-[(2-phenyl-5-trifluoromethyloxazole-4-carbonyl)amino]-3',4',5',6'-tetrahydro-2'H-(2,4'-bipyridinyl)-1'-carboxylic acid tert-butyl ester

: 1085841-79-7
2-phenyl-5-trifluoromethyloxazole-4-carboxylic acid (1',2',3',4',5',6'-hexahydro-(2,4'-bipyridin-5-yl)amide)

Guidance literature:: With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 2h; Inert atmosphere;
DOI:10.1021/jm101580m

Reference yield:

: 4487-59-6
2-bromo-5-nitropyridine

: 1085841-79-7
2-phenyl-5-trifluoromethyloxazole-4-carboxylic acid (1',2',3',4',5',6'-hexahydro-(2,4'-bipyridin-5-yl)amide)

Guidance literature:: Multi-step reaction with 4 steps

1: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium carbonate / ethanol; toluene / 0.67 h / 100 °C / Inert atmosphere; Microwave irradiation

2: palladium 10% on activated carbon; hydrogen / tetrahydrofuran; methanol / 2 h / 2585.81 Torr

3: triethylamine; bromo-tris(1-pyrrolidinyl)phosphonium hexafluorophosphate / N,N-dimethyl-formamide / Inert atmosphere

4: trifluoroacetic acid / dichloromethane / 2 h / 20 °C / Inert atmosphere

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; palladium 10% on activated carbon; hydrogen; potassium carbonate; triethylamine; bromo-tris(1-pyrrolidinyl)phosphonium hexafluorophosphate; trifluoroacetic acid; In tetrahydrofuran; methanol; ethanol; dichloromethane; N,N-dimethyl-formamide; toluene; 1: Suzuki coupling;
DOI:10.1021/jm101580m

Reference yield:

: 885693-48-1
5-amino-3',4',5',6'-tetrahydro-2'H-(2,4'-bipyridinyl)-1'-carboxylic acid tert-butyl ester

: 1085841-79-7
2-phenyl-5-trifluoromethyloxazole-4-carboxylic acid (1',2',3',4',5',6'-hexahydro-(2,4'-bipyridin-5-yl)amide)

Guidance literature:: Multi-step reaction with 2 steps

1: triethylamine; bromo-tris(1-pyrrolidinyl)phosphonium hexafluorophosphate / N,N-dimethyl-formamide / Inert atmosphere

2: trifluoroacetic acid / dichloromethane / 2 h / 20 °C / Inert atmosphere

With triethylamine; bromo-tris(1-pyrrolidinyl)phosphonium hexafluorophosphate; trifluoroacetic acid; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm101580m