5-AMINO-1-BOC-3',4',5',6'-TETRAHYDRO-2'H-[2,4']BIPYRIDINYL

Base Information

• Chemical Name: 5-AMINO-1-BOC-3',4',5',6'-TETRAHYDRO-2'H-[2,4']BIPYRIDINYL
• CAS No.: 885693-48-1
• Molecular Formula: C15H23 N3 O2
• Molecular Weight: 277.367
• Hs Code.: 2933990090
• Mol file: 885693-48-1.mol

Synonyms:5-AMINO-1-BOC-3’,4’,5’,6’-TETRAHYDRO-2’H-[2,4’]BIPYRIDINYL

Chemical Property of 5-AMINO-1-BOC-3',4',5',6'-TETRAHYDRO-2'H-[2,4']BIPYRIDINYL

Chemical Property:

• Vapor Pressure: 7.44E-07mmHg at 25°C
• Refractive Index: 1.539
• Boiling Point: 407.6°C at 760 mmHg
• PKA: 6.36±0.29(Predicted)
• Flash Point: 200.3°C
• PSA: 68.45000
• Density: 1.113g/cm³
• LogP: 3.29740
• Storage Temp.: 2-8°C

Purity/Quality:

97% ^*data from raw suppliers

tert-Butyl 4-(5-aminopyridin-2-yl)piperidine-1-carboxylate 95% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 5-AMINO-1-BOC-3',4',5',6'-TETRAHYDRO-2'H-[2,4']BIPYRIDINYL

There total 5 articles about 5-AMINO-1-BOC-3',4',5',6'-TETRAHYDRO-2'H-[2,4']BIPYRIDINYL which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

tert-butyl 5-nitro-5’,6’-dihydro-[2,4‘-bipyridine]-1‘(2’H)-carboxylate (885693-47-0) → 5-amino-3',4',5',6'-tetrahydro-2'H-(2,4'-bipyridinyl)-1'-carboxylic acid tert-butyl ester (885693-48-1)

Guidance literature:

With hydrogen; palladium 10% on activated carbon; In methanol; at 20 ℃; for 18h; under 760.051 Torr;

Reference yield: 42.0%

C15H21N3O4 (1085841-76-4) → 5-amino-3',4',5',6'-tetrahydro-2'H-(2,4'-bipyridinyl)-1'-carboxylic acid tert-butyl ester (885693-48-1)

Guidance literature:

With hydrogen; palladium 10% on activated carbon; In ethanol; for 20.5h;

Reference yield:

2-bromo-5-nitropyridine (4487-59-6) → 5-amino-3',4',5',6'-tetrahydro-2'H-(2,4'-bipyridinyl)-1'-carboxylic acid tert-butyl ester (885693-48-1)

Guidance literature:

Multi-step reaction with 2 steps

1: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium carbonate / ethanol; toluene / 0.67 h / 100 °C / Inert atmosphere; Microwave irradiation

2: palladium 10% on activated carbon; hydrogen / tetrahydrofuran; methanol / 2 h / 2585.81 Torr

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; palladium 10% on activated carbon; hydrogen; potassium carbonate; In tetrahydrofuran; methanol; ethanol; toluene; 1: Suzuki coupling;

DOI:10.1021/jm101580m

upstream raw materials:

tert-butyl 5-nitro-5’,6’-dihydro-[2,4‘-bipyridine]-1‘(2’H)-carboxylate

C₁₅H₂₁N₃O₄

2-bromo-5-nitropyridine

tert-Butyl 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-3,6-dihydro-1(2H)-pyridinecarboxylate

Downstream raw materials:

1,1-dimethylethyl 4-[5-({5-methyl-4-[(2-{[(1-methylethyl)amino]carbonyl}phenyl)amino]-2-pyrimidinyl}amino)-2-pyridinyl]-1-piperidinecarboxylate

2-phenyl-5-trifluoromethyloxazole-4-carboxylic acid (1'-cyclopropanecarbonyl-1',2',3',4',5',6'-hexahydro[2,4']bipyridinyl-5-yl)amide

4-{5-[(2-phenyl-5-trifluoromethyl-1,3-oxazole-4-carbonyl)amino]pyridin-2-yl}piperidine-1-carboxylic acid methyl ester

4-{5-[(2-phenyl-5-trifluoromethyloxazole-4-carbonyl)amino]-3',4',5',6'-tetrahydro-2'H-(2,4'-bipyridinyl)-1'-carbonyl}-trans-cyclohexanecarboxylic acid

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