N-((2-hydroxy-4,6-dimethylpyridin-3-yl)methyl)-2-methyl-1-phenyl-1H-indole-3-carboxamide

Base Information

Chemical Name:N-((2-hydroxy-4,6-dimethylpyridin-3-yl)methyl)-2-methyl-1-phenyl-1H-indole-3-carboxamide
CAS No.:1450651-79-2
Molecular Formula:C₂₄H₂₃N₃O₂
Molecular Weight:385.466
Hs Code.:

Synonyms:N-((2-hydroxy-4,6-dimethylpyridin-3-yl)methyl)-2-methyl-1-phenyl-1H-indole-3-carboxamide

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Chemical Property of N-((2-hydroxy-4,6-dimethylpyridin-3-yl)methyl)-2-methyl-1-phenyl-1H-indole-3-carboxamide

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Technology Process of N-((2-hydroxy-4,6-dimethylpyridin-3-yl)methyl)-2-methyl-1-phenyl-1H-indole-3-carboxamide

There total 4 articles about N-((2-hydroxy-4,6-dimethylpyridin-3-yl)methyl)-2-methyl-1-phenyl-1H-indole-3-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 50.0%

: 771579-27-2
3-(aminomethyl)-4,6-dimethylpyridin-2-ol

: 1450658-33-9
2-methyl-1-phenyl-1H-indole-3-carboxylic caid

: 1450651-79-2
N-((2-hydroxy-4,6-dimethylpyridin-3-yl)methyl)-2-methyl-1-phenyl-1H-indole-3-carboxamide

Guidance literature:: 2-methyl-1-phenyl-1H-indole-3-carboxylic caid; With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In dichloromethane; at 20 ℃; for 0.5h;

3-(aminomethyl)-4,6-dimethylpyridin-2-ol; In dichloromethane; at 20 ℃; for 3h;

Reference yield:

: 65417-22-3
methyl 2-methyl-1H-indole-3-carboxylate

: 1450651-79-2
N-((2-hydroxy-4,6-dimethylpyridin-3-yl)methyl)-2-methyl-1-phenyl-1H-indole-3-carboxamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: copper diacetate; dmap; triethylamine / dichloromethane / 12 h / 20 °C / Molecular sieve

2.1: water; lithium hydroxide / ethanol; water / 8 h / 20 °C

3.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol; triethylamine / dichloromethane / 0.5 h / 20 °C

3.2: 3 h / 20 °C

With dmap; water; copper diacetate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; lithium hydroxide; In ethanol; dichloromethane; water;

Reference yield:

: 1450658-32-8
methyl 2-methyl-1-phenyl-1H-indole-3-carboxylate

: 1450651-79-2
N-((2-hydroxy-4,6-dimethylpyridin-3-yl)methyl)-2-methyl-1-phenyl-1H-indole-3-carboxamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: water; lithium hydroxide / ethanol; water / 8 h / 20 °C

2.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol; triethylamine / dichloromethane / 0.5 h / 20 °C

2.2: 3 h / 20 °C

With water; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; lithium hydroxide; In ethanol; dichloromethane; water;