ethyl 1-(5-chloro-2-methoxybenzyl)-3-(4-methyl-2-pivalamidothiazol-5-yl)-1H-pyrazole-5-carboxylate

Base Information

Chemical Name:ethyl 1-(5-chloro-2-methoxybenzyl)-3-(4-methyl-2-pivalamidothiazol-5-yl)-1H-pyrazole-5-carboxylate
CAS No.:1402464-42-9
Molecular Formula:C₂₃H₂₇ClN₄O₄S
Molecular Weight:491.011
Hs Code.:

Synonyms:ethyl 1-(5-chloro-2-methoxybenzyl)-3-(4-methyl-2-pivalamidothiazol-5-yl)-1H-pyrazole-5-carboxylate

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Chemical Property of ethyl 1-(5-chloro-2-methoxybenzyl)-3-(4-methyl-2-pivalamidothiazol-5-yl)-1H-pyrazole-5-carboxylate

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Technology Process of ethyl 1-(5-chloro-2-methoxybenzyl)-3-(4-methyl-2-pivalamidothiazol-5-yl)-1H-pyrazole-5-carboxylate

There total 1 articles about ethyl 1-(5-chloro-2-methoxybenzyl)-3-(4-methyl-2-pivalamidothiazol-5-yl)-1H-pyrazole-5-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1224177-84-7,1402464-40-7
ethyl 3-(4-methyl-2-pivalamidothiazol-5-yl)-1H-pyrazole-5-carboxylate

: 58735-58-3
2-(bromomethyl)-4-chloro-1-methoxybenzene

: C₂₃H₂₇ClN₄O₄S

: 1402464-42-9
ethyl 1-(5-chloro-2-methoxybenzyl)-3-(4-methyl-2-pivalamidothiazol-5-yl)-1H-pyrazole-5-carboxylate

: C₃₁H₃₄Cl₂N₄O₅S

Guidance literature:: With potassium carbonate; In acetone; at 60 ℃; for 24h;
DOI:10.1021/jm100235h

Reference yield: 87.0%

: 110-91-8,99108-56-2
morpholine

: 1402464-42-9
ethyl 1-(5-chloro-2-methoxybenzyl)-3-(4-methyl-2-pivalamidothiazol-5-yl)-1H-pyrazole-5-carboxylate

: 1402464-44-1
N-(5-(1-(5-chloro-2-methoxybenzyl)-5-(morpholine-4-carbonyl)-1H-pyrazol-3-yl)-4-methylthiazol-2-yl)pivalamide

Guidance literature:: ethyl 1-(5-chloro-2-methoxybenzyl)-3-(4-methyl-2-pivalamidothiazol-5-yl)-1H-pyrazole-5-carboxylate; With trimethylaluminum; In dichloromethane; at 0 ℃; for 0.166667h;

morpholine; In dichloromethane; at 100 ℃; for 0.666667h; Microwave irradiation;
DOI:10.1021/jm100235h

Reference yield: 75.0%

: 1402464-42-9
ethyl 1-(5-chloro-2-methoxybenzyl)-3-(4-methyl-2-pivalamidothiazol-5-yl)-1H-pyrazole-5-carboxylate

: 104-94-9
4-methoxy-aniline

: 1402464-43-0
1-(5-chloro-2-methoxybenzyl)-N-(4-methoxyphenyl)-3-(4-methyl-2-pivalamidothiazol-5-yl)-1H-pyrazole-5-carboxamide

Guidance literature:: ethyl 1-(5-chloro-2-methoxybenzyl)-3-(4-methyl-2-pivalamidothiazol-5-yl)-1H-pyrazole-5-carboxylate; With trimethylaluminum; In dichloromethane; at 0 ℃; for 0.166667h;

4-methoxy-aniline; In dichloromethane; at 100 ℃; for 0.666667h; Microwave irradiation;
DOI:10.1021/jm100235h