Piperidino disulfide

Base Information

• Chemical Name: Piperidino disulfide
• CAS No.: 10220-20-9
• Molecular Formula: C10H20 N2 S2
• Molecular Weight: 232.414
• Hs Code.: 2933399090
• European Community (EC) Number: 621-456-2
• DSSTox Substance ID: DTXSID20144733
• Nikkaji Number: J50.661C
• Wikidata: Q83008985
• ChEMBL ID: CHEMBL573921
• Mol file: 10220-20-9.mol

Synonyms:Piperidino disulfide;10220-20-9;1,1'-Dithiodipiperidine;Bispiperidino disulfide;1-(piperidin-1-yldisulfanyl)piperidine;N,N'-Dithiobis(piperidine);1,1'-Dithiobis(piperidine);Piperidine, 1,1-dithiobis-;PIPERIDINE, 1,1'-DITHIODI-;Piperidine, 1,1'-dithiobis-;N,N'-Dipiperidino-disulfid;Dipiperidino disulfide;N,N'-Dipiperidino-disulfid [German];BRN 0115167;CHEMBL573921;C10H20N2S2;1 1/'-DITHIOBISPIPERIDINE 99;5-20-03-00487 (Beilstein Handbook Reference);dithiobispiperidine;1 1'-DITHIOBISPIPERIDINE 99;N,N'-Dithiobispiperidine;1,1'-disulfanediyldipiperidine;SCHEMBL5328404;1 1'-DITHIOBISPIPERIDINE;DTXSID20144733;1-(1-piperidyldisulfanyl)piperidine;BDBM50414923;STL327191;AKOS015913599;1-(1-Piperidinyldisulfanyl)piperidine #;BP-30131;LS-115303

Chemical Property of Piperidino disulfide

Chemical Property:

• Melting Point: 65-68 °C(lit.)
• Refractive Index: 1.5500 (estimate)
• Boiling Point: 339.5°Cat760mmHg
• Flash Point: 159.1°C
• PSA: 57.08000
• Density: 1.17g/cm³
• LogP: 3.04540
• XLogP3: 3.1
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 3
• Exact Mass: 232.10679099
• Heavy Atom Count: 14
• Complexity: 136

Purity/Quality:

98%,99%, ^*data from raw suppliers

1 1'-DITHIOBISPIPERIDINE 95.00% ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1CCN(CC1)SSN2CCCCC2

Technology Process of Piperidino disulfide

There total 6 articles about Piperidino disulfide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

piperidine (110-89-4) → 1,1'-dithiobispiperidine (10220-20-9)

Guidance literature:

With disulfur dichloride; sodium hydroxide; In dichloromethane; water; Cooling with ice;

DOI:10.1021/jf900324a

Reference yield:

piperidine (110-89-4) + disulfur dithiocyanate (155816-23-2) → 1,1'-dithiobispiperidine (10220-20-9) + piperidine thiocyanate (22205-64-7)

Guidance literature:

With tetrachloromethane; at 0 ℃;

Reference yield:

piperidine (110-89-4) + hexathionate (31294-89-0) → 1,1'-dithiobispiperidine (10220-20-9) + thiosulphate ion (14383-50-7)

Guidance literature:

In not given; byproducts: C5H10NH2(1+);

upstream raw materials:

piperidine

O,O-dimethyl thiosulfite

disulfur dithiocyanate

hexathionate

Downstream raw materials:

piperidine

bis-(toluene-4-sulfonyl)-disulfane

piperidino p-toluenesulfonyl disulfide

2-phenyl-6-piperidin-1-ylsulfanyl-2,3-dihydro-[1,4]dithiino[2,3-c]pyrrole-5,7-dione

Refernces

• 1、 Kapanda, Coco N.,Muccioli, Giulio G.,Labar, Geoffray,Poupaert, Jacques H.,Lambert, Didier M.. "Bis(dialkylaminethiocarbonyl)disulfides as potent and selective monoglyceride lipase inhibitors". experimental part. p. 7310 - 7314. Retrieved 2010/07/14.
• 2、 Beerheide, Walter,Sim, Mui Mui,Tan, Yee-Joo,Bernard, Hans-Ulrich,Ting, Anthony E. "Inactivation of the human papillomavirus-16 E6 oncoprotein by organic disulfides". . p. 2549 - 2560. Retrieved 2007/10/03.