1-[(4-Chlorophenyl)sulfonyl]-D-proline

Base Information

Chemical Name:1-[(4-Chlorophenyl)sulfonyl]-D-proline
CAS No.:910481-88-8
Molecular Formula:C₁₁H₁₂ClNO₄S
Molecular Weight:289.74
Hs Code.:
DSSTox Substance ID:DTXSID901282101

Synonyms:DTXSID901282101;AKOS017337143;1-[(4-Chlorophenyl)sulfonyl]-D-proline;910481-88-8

Suppliers and Price of 1-[(4-Chlorophenyl)sulfonyl]-D-proline

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

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Chemical Property of 1-[(4-Chlorophenyl)sulfonyl]-D-proline

Chemical Property:

XLogP3:1.8
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:3
Exact Mass:289.0175567
Heavy Atom Count:18
Complexity:411

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:C1CC(N(C1)S(=O)(=O)C2=CC=C(C=C2)Cl)C(=O)O
Isomeric SMILES:C1C[C@@H](N(C1)S(=O)(=O)C2=CC=C(C=C2)Cl)C(=O)O

Technology Process of 1-[(4-Chlorophenyl)sulfonyl]-D-proline

There total 1 articles about 1-[(4-Chlorophenyl)sulfonyl]-D-proline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 98-60-2
4-chlorobenzenesulfonyl chloride

: 344-25-2,25191-13-3,37159-97-0,4305-67-3,4607-28-7
D-Prolin

: 910481-88-8,251096-94-3
(R)-1-(4-chlorophenylsulfonyl)pyrrolidine-2-carboxylic acid

Guidance literature:: With sodium hydroxide; In tetrahydrofuran; at 20 ℃;
DOI:10.1021/jm050849w

Reference yield: 52.0%

: 910481-88-8,251096-94-3
(R)-1-(4-chlorophenylsulfonyl)pyrrolidine-2-carboxylic acid

: (S)-(-)-2-amino-3-phenyl-1-propanol hydrochloride salt

: 910482-04-1
(R)-1-(4-chlorophenylsulfonyl)-N-((S)-1-hydroxy-3-phenylpropan-2-yl)pyrrolidine-2-carboxamide

Guidance literature:: With 4-methyl-morpholine; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; In dichloromethane; at 20 ℃;
DOI:10.1021/jm050849w

Reference yield:

: 910481-88-8,251096-94-3
(R)-1-(4-chlorophenylsulfonyl)pyrrolidine-2-carboxylic acid

: (R)-1-(4-Chloro-benzenesulfonyl)-pyrrolidine-2-carboxylic acid (1-formyl-2-phenyl-ethyl)-amide

Guidance literature:: Multi-step reaction with 2 steps

1: 52 percent / EDC; HOBT; NMM / CH₂Cl₂ / 20 °C

2: 56.9 percent / Dess-Martin reagent / CH₂Cl₂ / 2 h / 20 °C

With 4-methyl-morpholine; benzotriazol-1-ol; Dess-Martin periodane; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; In dichloromethane; 2: Dess-Martin oxidation;
DOI:10.1021/jm050849w