[(R)-1-((1R,2S)-2-Diethylcarbamoyl-2-phenyl-cyclopropyl)-2-hydroxy-ethyl]-carbamic acid tert-butyl ester

Base Information

• Chemical Name: [(R)-1-((1R,2S)-2-Diethylcarbamoyl-2-phenyl-cyclopropyl)-2-hydroxy-ethyl]-carbamic acid tert-butyl ester
• CAS No.: 213018-90-7
• Molecular Formula: C₂₁H₃₂N₂O₄
• Molecular Weight: 376.496

Synonyms:[(R)-1-((1R,2S)-2-Diethylcarbamoyl-2-phenyl-cyclopropyl)-2-hydroxy-ethyl]-carbamic acid tert-butyl ester

Chemical Property of [(R)-1-((1R,2S)-2-Diethylcarbamoyl-2-phenyl-cyclopropyl)-2-hydroxy-ethyl]-carbamic acid tert-butyl ester

Chemical Property:

Purity/Quality:

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Technology Process of [(R)-1-((1R,2S)-2-Diethylcarbamoyl-2-phenyl-cyclopropyl)-2-hydroxy-ethyl]-carbamic acid tert-butyl ester

There total 3 articles about [(R)-1-((1R,2S)-2-Diethylcarbamoyl-2-phenyl-cyclopropyl)-2-hydroxy-ethyl]-carbamic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

(R)-tert-Butoxycarbonylamino-((1R,2S)-2-diethylcarbamoyl-2-phenyl-cyclopropyl)-acetic acid methyl ester (213018-89-4) → [(R)-1-((1R,2S)-2-Diethylcarbamoyl-2-phenyl-cyclopropyl)-2-hydroxy-ethyl]-carbamic acid tert-butyl ester (213018-90-7)

Guidance literature:

With diisobutylaluminium hydride; In tetrahydrofuran; 1.) -78 deg C, 1 h, 2.) RT, 15 h;

DOI:10.1021/jm980238m

Reference yield:

di-tert-butyl dicarbonate (24424-99-5) → [(R)-1-((1R,2S)-2-Diethylcarbamoyl-2-phenyl-cyclopropyl)-2-hydroxy-ethyl]-carbamic acid tert-butyl ester (213018-90-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 96 percent / acetonitrile / 1.5 h / Ambient temperature

2: 60 percent / DIBAL-H / tetrahydrofuran / 1.) -78 deg C, 1 h, 2.) RT, 15 h

With diisobutylaluminium hydride; In tetrahydrofuran; acetonitrile;

DOI:10.1021/jm980238m

Reference yield:

(1S,2R)-2-((R)-Amino-cyano-methyl)-1-phenyl-cyclopropanecarboxylic acid diethylamide; hydrochloride → [(R)-1-((1R,2S)-2-Diethylcarbamoyl-2-phenyl-cyclopropyl)-2-hydroxy-ethyl]-carbamic acid tert-butyl ester (213018-90-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 96 percent / acetonitrile / 1.5 h / Ambient temperature

2: 60 percent / DIBAL-H / tetrahydrofuran / 1.) -78 deg C, 1 h, 2.) RT, 15 h

With diisobutylaluminium hydride; In tetrahydrofuran; acetonitrile;

DOI:10.1021/jm980238m

upstream raw materials:

(R)-tert-Butoxycarbonylamino-((1R,2S)-2-diethylcarbamoyl-2-phenyl-cyclopropyl)-acetic acid methyl ester

di-tert-butyl dicarbonate

Downstream raw materials:

[(S)-1-((1R,2S)-2-Diethylcarbamoyl-2-phenyl-cyclopropyl)-allyl]-carbamic acid tert-butyl ester

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