(R)-tert-Butoxycarbonylamino-((1R,2S)-2-diethylcarbamoyl-2-phenyl-cyclopropyl)-acetic acid methyl ester

Base Information

Chemical Name:(R)-tert-Butoxycarbonylamino-((1R,2S)-2-diethylcarbamoyl-2-phenyl-cyclopropyl)-acetic acid methyl ester
CAS No.:213018-89-4
Molecular Formula:C₂₂H₃₂N₂O₅
Molecular Weight:404.506
Hs Code.:

Synonyms:(R)-tert-Butoxycarbonylamino-((1R,2S)-2-diethylcarbamoyl-2-phenyl-cyclopropyl)-acetic acid methyl ester

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Chemical Property of (R)-tert-Butoxycarbonylamino-((1R,2S)-2-diethylcarbamoyl-2-phenyl-cyclopropyl)-acetic acid methyl ester

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Technology Process of (R)-tert-Butoxycarbonylamino-((1R,2S)-2-diethylcarbamoyl-2-phenyl-cyclopropyl)-acetic acid methyl ester

There total 1 articles about (R)-tert-Butoxycarbonylamino-((1R,2S)-2-diethylcarbamoyl-2-phenyl-cyclopropyl)-acetic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 24424-99-5
di-tert-butyl dicarbonate

: (1S,2R)-2-((R)-Amino-cyano-methyl)-1-phenyl-cyclopropanecarboxylic acid diethylamide; hydrochloride

: 213018-89-4
(R)-tert-Butoxycarbonylamino-((1R,2S)-2-diethylcarbamoyl-2-phenyl-cyclopropyl)-acetic acid methyl ester

Guidance literature:: In acetonitrile; for 1.5h; Ambient temperature;
DOI:10.1021/jm980238m

Reference yield: 60.0%

: 213018-89-4
(R)-tert-Butoxycarbonylamino-((1R,2S)-2-diethylcarbamoyl-2-phenyl-cyclopropyl)-acetic acid methyl ester

: 213018-90-7
[(R)-1-((1R,2S)-2-Diethylcarbamoyl-2-phenyl-cyclopropyl)-2-hydroxy-ethyl]-carbamic acid tert-butyl ester

Guidance literature:: With diisobutylaluminium hydride; In tetrahydrofuran; 1.) -78 deg C, 1 h, 2.) RT, 15 h;
DOI:10.1021/jm980238m

Reference yield:

: 213018-89-4
(R)-tert-Butoxycarbonylamino-((1R,2S)-2-diethylcarbamoyl-2-phenyl-cyclopropyl)-acetic acid methyl ester

: 171889-33-1
[(S)-1-((1R,2S)-2-Diethylcarbamoyl-2-phenyl-cyclopropyl)-allyl]-carbamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 60 percent / DIBAL-H / tetrahydrofuran / 1.) -78 deg C, 1 h, 2.) RT, 15 h

2: 1.) oxalyl chloride, DMSO, 2.) Et₃N / 1.) CH₂Cl₂, -78 deg C, 2 h, 2.) CH₂Cl₂, -78 deg C, 1 h

3: 1.) BuLi / 1.) THF, hexane, -21 deg C, 30 min, 2.) THF, -21 deg C, 1.5 h

With n-butyllithium; oxalyl dichloride; diisobutylaluminium hydride; dimethyl sulfoxide; triethylamine; In tetrahydrofuran;
DOI:10.1021/jm980238m