7-chloro-2-iodo-5,8-dimethoxy-1-methoxymethoxy-3-[(3-p-methoxyphenyl-2-propynoyloxy)methyl]naphthalene

Base Information

Chemical Name:7-chloro-2-iodo-5,8-dimethoxy-1-methoxymethoxy-3-[(3-p-methoxyphenyl-2-propynoyloxy)methyl]naphthalene
CAS No.:271250-53-4
Molecular Formula:C₂₅H₂₂ClIO₇
Molecular Weight:596.803
Hs Code.:

Synonyms:7-chloro-2-iodo-5,8-dimethoxy-1-methoxymethoxy-3-[(3-p-methoxyphenyl-2-propynoyloxy)methyl]naphthalene

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Chemical Property of 7-chloro-2-iodo-5,8-dimethoxy-1-methoxymethoxy-3-[(3-p-methoxyphenyl-2-propynoyloxy)methyl]naphthalene

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Technology Process of 7-chloro-2-iodo-5,8-dimethoxy-1-methoxymethoxy-3-[(3-p-methoxyphenyl-2-propynoyloxy)methyl]naphthalene

There total 5 articles about 7-chloro-2-iodo-5,8-dimethoxy-1-methoxymethoxy-3-[(3-p-methoxyphenyl-2-propynoyloxy)methyl]naphthalene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 2227-57-8
3-(4-methoxyphenyl)propynoic acid

: 241149-23-5
7-chloro-3-hydroxymethyl-2-iodo-5,8-dimethoxy-1-(methoxymethoxy)naphthalene

: 271250-53-4
7-chloro-2-iodo-5,8-dimethoxy-1-methoxymethoxy-3-[(3-p-methoxyphenyl-2-propynoyloxy)methyl]naphthalene

Guidance literature:: With N,N-bis[2-oxo-3-oxazolidinyl]phosphorodiamidic chloride; triethylamine; In dichloromethane; at 20 ℃; for 20h;
DOI:10.1039/b007859j

Reference yield:

: 152039-15-1
6-Chloro-4-hydroxy-5,8-dimethoxy-2-(hydroxymethyl)naphthalene

: 271250-53-4
7-chloro-2-iodo-5,8-dimethoxy-1-methoxymethoxy-3-[(3-p-methoxyphenyl-2-propynoyloxy)methyl]naphthalene

Guidance literature:: Multi-step reaction with 5 steps

1.1: 90 percent / con. HClO₄ / CH₂Cl₂ / 2 h / 20 °C

2.1: 77 percent / I₂; N-methylmorpholine / CH₂Cl₂ / 3 h / 20 °C

3.1: NaH / dimethylformamide

3.2: 88 percent / dimethylformamide / 6 h

4.1: 92 percent / aq. NaOH / tetrahydrofuran; methanol / 1 h / 20 °C

5.1: 86 percent / N,N-bis(2-oxooxazolidin-3-yl)phosphorodiamidic chloride; Et₃N / CH₂Cl₂ / 20 h / 20 °C

With 4-methyl-morpholine; sodium hydroxide; perchloric acid; N,N-bis[2-oxo-3-oxazolidinyl]phosphorodiamidic chloride; iodine; sodium hydride; triethylamine; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1039/b007859j

Reference yield:

: 241149-21-3
3-acetoxymethyl-7-chloro-2-iodo-5,8-dimethoxy-1-naphthol

: 271250-53-4
7-chloro-2-iodo-5,8-dimethoxy-1-methoxymethoxy-3-[(3-p-methoxyphenyl-2-propynoyloxy)methyl]naphthalene

Guidance literature:: Multi-step reaction with 3 steps

1.1: NaH / dimethylformamide

1.2: 88 percent / dimethylformamide / 6 h

2.1: 92 percent / aq. NaOH / tetrahydrofuran; methanol / 1 h / 20 °C

3.1: 86 percent / N,N-bis(2-oxooxazolidin-3-yl)phosphorodiamidic chloride; Et₃N / CH₂Cl₂ / 20 h / 20 °C

With sodium hydroxide; N,N-bis[2-oxo-3-oxazolidinyl]phosphorodiamidic chloride; sodium hydride; triethylamine; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1039/b007859j