Welcome to LookChem.com Sign In|Join Free
  • or
3-(4-methoxyphenyl)-2-propynoic acid (SALTDATA: FREE), also known as cas# 2227-57-8, is an organic compound with a unique structure featuring a propynoic acid backbone and a 4-methoxyphenyl group. This molecule is characterized by its reactivity and potential applications in various chemical synthesis processes.

2227-57-8

Post Buying Request

2227-57-8 Suppliers

Recommended suppliers

  • Product
  • FOB Price
  • Min.Order
  • Supply Ability
  • Supplier
  • Contact Supplier

2227-57-8 Usage

Uses

Used in Chemical Synthesis:
3-(4-methoxyphenyl)-2-propynoic acid (SALTDATA: FREE) is used as a reagent for the preparation of bis(phenylethynyl)benzenes. Its unique structure allows for the formation of these complex organic molecules, which have potential applications in various fields such as materials science, pharmaceuticals, and chemical research.

Check Digit Verification of cas no

The CAS Registry Mumber 2227-57-8 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 2,2,2 and 7 respectively; the second part has 2 digits, 5 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 2227-57:
(6*2)+(5*2)+(4*2)+(3*7)+(2*5)+(1*7)=68
68 % 10 = 8
So 2227-57-8 is a valid CAS Registry Number.
InChI:InChI=1/C10H8O3/c1-13-9-5-2-8(3-6-9)4-7-10(11)12/h2-3,5-6H,1H3,(H,11,12)

2227-57-8SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 19, 2017

Revision Date: Aug 19, 2017

1.Identification

1.1 GHS Product identifier

Product name 3-(4-methoxyphenyl)prop-2-ynoic acid

1.2 Other means of identification

Product number -
Other names -

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:2227-57-8 SDS

2227-57-8Relevant academic research and scientific papers

An efficient nanoscale heterogeneous catalyst for the capture and conversion of carbon dioxide at ambient pressure

Liu, Xiao-Huan,Ma, Jian-Gong,Niu, Zheng,Yang, Guang-Ming,Cheng, Peng

, p. 988 - 991 (2015)

Silver nanoparticles were successfully supported on the zeolite-type metal-organic framework MIL-101 to yield Ag@MIL-101 by a simple liquid impregnation method. For the first time, the conversion of terminal alkynes into propiolic acids with CO2 was achieved by the use of the Ag@MIL-101 catalysts. Owing to the excellent catalytic activity, the reaction proceeded at atmospheric pressure and low temperature (50 8C). The Ag@MIL-101 porous material is of outstanding bifunctional character as it is capable of simultaneously capturing and converting CO2 with low energy consumption and can be recovered easily by centrifugation.

Gold-Catalyzed Post-Ugi Cascade Transformation for the Synthesis of 2-Pyridones

Du, Xiaochen,Yu, Jiafeng,Gong, Jing,Zaman, Manzoor,Pereshivko, Olga P.,Peshkov, Vsevolod A.

, p. 2502 - 2507 (2019)

A gold-catalyzed post-Ugi cascade transformation for the synthesis of 2-pyridones is described. The process involves furan–alkyne cyclization followed by furan ring-opening and cleavage of the isocyanide-originated fragment. The initially formed cis double bond can isomerize into a more stable trans double bond upon prolonged exposure to a strong Br?nsted acid. Thus, the overall strategy provides a viable access towards two types of 2-pyridones.

Composite System of Ag Nanoparticles and Metal-Organic Frameworks for the Capture and Conversion of Carbon Dioxide under Mild Conditions

Zhu, Ning-Ning,Liu, Xiao-Huan,Li, Tao,Ma, Jian-Gong,Cheng, Peng,Yang, Guang-Ming

, p. 3414 - 3420 (2017)

The materials Ag@MIL-100(Fe) and Ag@UIO-66(Zr) are obtained for the capture and transformation of CO2 into alkynyl carboxylic acids, which are environmental friendly, facile to synthesize, and exhibit excellent efficiency and reusability. The influence on the catalytic activity of such Ag@MOF systems by metal-organic frameworks' (MOFs) surface area, thermal, and chemical stability, especially the acid-base characteristics of the pores, are compared and discussed systematically.

An efficient Ag/MIL-100(Fe) catalyst for photothermal conversion of CO2 at ambient temperature

Jing, Peng,Wu, Boyuan,Han, Zongsu,Shi, Wei,Cheng, Peng

, p. 3505 - 3508 (2021)

The conversion of CO2 under mild condition is of great importance because these reactions involving CO2 can not only produce value-added chemicals from abundant and inexpensive CO2 feedstock but also close the carbon cycle. However, the chemical inertness of CO2 requires the development of high-performance catalysts. Herein, Ag nanoparticles/MIL-100(Fe) composites were synthesized by simple impregnation-reduction method and employed as catalysts for the photothermal carboxylation of terminal alkynes with CO2. MIL-100(Fe) could stabilize Ag nanoparticles and prevent them from aggregation during catalytic process. Taking the advantages of photothermal effects and catalytic activities of both Ag nanoparticles and MIL-100(Fe), various aromatic alkynes could be converted to corresponding carboxylic acid products (86%–92% yields) with 1 atm CO2 at room temperature under visible light irradiation when using Ag nanoparticles/MIL-100(Fe) as photothermal catalysts. The catalysts also showed good recyclability with almost no loss of catalytic activity for three consecutive runs. More importantly, the catalytic performance of Ag nanoparticles/MIL-100(Fe) under visible light irradiation at room temperature was comparable to that upon heating, showing that the light source could replace conventional heating method to drive the reaction. This work provided a promising strategy of utilizing solar energy for achieving efficient CO2 conversion to value-added chemicals under mild condition.

Hierarchically porous covalent organic frameworks assembled in ionic liquids for highly effective catalysis of C-C coupling reactions

Gao, Hongshuai,Guan, Pengxin,Li, Zhiyong,Qiu, Jikuan,Wang, Huiyong,Wang, Jianji,Zhang, Hucheng,Zhang, Suojiang,Zhao, Yuling

, p. 2605 - 2612 (2020)

Although significant progress has been made in the synthesis of covalent organic frameworks (COFs) in recent years, the construction of hierarchical pores in such materials remains a great challenge. Herein, we report a facile synthesis of hierarchically porous COFs (HP-COFs) under mild conditions in ionic liquids 1-alkyl-3-methylimidazolium tetrafluoroborates ([Cnmim][BF4], n = 4, 6, 10). It has been found that apart from the inherent micropores, a large mesoporous structure has been produced in the COFs in which the size of pores can be simply tuned by adjusting the alkyl chain length of the ionic liquids. These mesopores have been confirmed by N2 sorption and electron microscopy techniques. Importantly, this approach is applicable for the preparation of various HP-COFs, such as imine and hydrazone based COFs, which are quite difficult to acquire through traditional methods. In addition, these HP-COFs show highly effective catalytic performance for C-C bond formation, especially for large size molecule based C-C coupling reactions in comparison with uni-pore COFs.

Organocatalytic Strategy for the Fixation of CO2via Carboxylation of Terminal Alkynes

Shi, Jun-Bin,Bu, Qingqing,Liu, Bin-Yuan,Dai, Bin,Liu, Ning

, p. 1850 - 1860 (2021/01/14)

An organocatalytic strategy for the direct carboxylation of terminal alkynes with CO2 has been developed. The combined use of a bifunctional organocatalyst and Cs2CO3 resulted in a robust catalytic system for the preparation of a range of propiolic acid derivatives in high yields with broad substrate scope using CO2 at atmospheric pressure under mild temperatures (60 °C). This work has demonstrated that this organocatalytic method offers a competitive alternative to metal catalysis for the carboxylation of terminal alkynes and CO2. In addition, this protocol was suitable for the three-component carboxylation of terminal alkynes, alkyl halides, and CO2.

Pre-carbonized nitrogen-rich polytriazines for the controlled growth of silver nanoparticles: Catalysts for enhanced CO2chemical conversion at atmospheric pressure

Liu, Jian,Zhang, Xiaoyi,Wen, Bingyan,Li, Yipei,Wu, Jingjing,Wang, Zhipeng,Wu, Ting,Zhao, Rusong,Yang, Shenghong

, p. 3119 - 3127 (2021/05/25)

High catalytic activity and sufficient durability are two unavoidable key indices of an efficient heterogeneous catalyst for the direct carboxylation of terminal alkynes with CO2 conversion. Nitrogen-rich covalent triazine frameworks (CTFs) are promising substrates, while random distribution of some residual -NH2 groups brings challenges to the controlled growth of catalytic species. Here, we adopt a pre-carbonization protocol, annealing below the carbonization temperature, to eliminate the random -NH2 groups in CTFs and meanwhile to promote polycondensation degree under the premise of maintaining the pore structure. Benefiting from the improved condensation and orderly N atoms, p-CTF-250, for which CTFs are annealed at 250 °C, exhibits improved CO2 adsorption capacity and the ability to control the growth of Ag NPs. Mono-dispersed Ag NPs are generated controllably and entrapped to form Ag@p-CTF-250 catalysts. These Ag@p-CTF-250 catalysts were employed in the direct carboxylation of various terminal alkynes with CO2 under mild conditions (50 °C, 1 atm) and showed excellent catalytic activity. In addition, these catalysts have robust recyclability and can be used for at least 5 catalytic runs while retaining yield above 90%. CO2 conversion proceeds well under the synergistic effect between the high CO2 capture capability and the uniform tiny Ag NPs in Ag@p-CTF-250 "nanoreactors". The results represent an efficient strategy for controlling the growth of metallic nanoparticles in porous organic polymer substrates containing disordered heteroatoms.

Copper(I)-modified covalent organic framework for CO2 insertion to terminal alkynes

Bu, Ran,Zhang, Lin,Gao, Lu-Lu,Sun, Weng-Jie,Yang, Shuai-Liang,Gao, En-Qing

, (2020/12/21)

The carboxylation of terminal alkynes with CO2 is an attractive route for CO2 fixation and conversion, and various homogeneous Cu(I) catalysts have been explored for the reaction. However, it is still a challenge to develop efficient heterogeneous catalysts for the conversion under mild conditions. Considering that covalent organic frameworks (COFs) are emerging as versatile platforms for the design of functional materials, we developed a TpBpy-supported Cu(I) catalyst, where TpBpy is a stable imine-type porous COF furnished with rich N,N- and N,O-chelating sites for Cu(I) immobilization. The hybrid material can efficiently catalyze the conversion of CO2 and terminal alkynes to propiolic acids under relatively mild conditions (1 atm CO2, 60 ℃). The catalytic activity arises from the synergy between the organic framework of TpBpy and the Cu(I) sites. Not merely serving as a porous support to afford isolated and accessible Cu(I) sites, the organic framework itself has its own catalytic activity through the polar and basic N and O functional sites, which could activate the C–H bond and facilitate CO2 absorption. In addition, the framework also serves as a giant ligand to shift the reversible Cu(I)-catalyzed process in favor of carboxylation. The catalyst shows somewhat reduced activity after reused for three cycles owing to the oxidation of Cu(I) to Cu(II), but it can be easily regenerated by treating with KI.

N-Heterocyclic carbene-nitrogen molybdenum catalysts for utilization of CO2

Chen, Fei,Tao, Sheng,Liu, Ning,Dai, Bin

, (2021/01/19)

Three new N-heterocyclic carbene-nitrogen molybdenum complex was synthesized, and its catalytic activity was evaluated in the cycloaddition of epoxides with CO2. The molybdenum complex combined with tetrabutyl ammonium iodide (TBAI) resulted in a catalytic system for efficient conversion of a wide range of terminal and internal epoxides under 80 °C and 5–7 bar pressure for CO2. The cooperative catalysis mechanism between molybdenum complex and TBAI was elucidated, in which molybdenum complex was used as Lewis acid, and TBAI was employed as nucleophilic reagent. In addition, the NHC-Mo catalytic system was also successfully applied for the direct carboxylation of terminal alkynes with CO2.

Microwave-assisted fabrication of a mixed-ligand [Cu4(μ3-OH)2]-cluster-based metal–organic framework with coordinatively unsaturated metal sites for carboxylation of terminal alkynes with carbon dioxide

Wang, Wen-Jing,Sun, Zhong-Hua,Chen, Sheng-Chun,Qian, Jun-Feng,He, Ming-Yang,Chen, Qun

, (2021/05/24)

The development of efficient and stable metal–organic framework (MOF) catalysts with coordinatively unsaturated metal sites for modern organic synthesis is greatly important. Herein, a robust [Cu4(μ3-OH)2]-cluster-based MOF (Cu-MOF) with a mixed-ligand system was successfully fabricated by a microwave-assisted method under mild conditions. The as-prepared Cu-MOF catalyst possessing unsaturated Cu (II) sites exhibited excellent catalytic activity toward the direct carboxylation of 1-ethynylbenzene with CO2, and various propiolic acid derivatives were synthesized in moderate to good yields under optimized reaction conditions. Furthermore, the catalyst remained stable and could be easily recycled for five sequential runs without incredible decrease in catalytic efficiency.

Post a RFQ

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

1 Customer Service

What can I do for you?
Get Best Price

Get Best Price for 2227-57-8