5-(4-(6-(4-(2,2-dimethyl-1,3-dioxan-5-yl)phenoxy)-5-methylpyrimidin-4-yloxy)piperidin-1-yl)-3-isopropyl-1,2,4-oxadiazole

Base Information

• Chemical Name: 5-(4-(6-(4-(2,2-dimethyl-1,3-dioxan-5-yl)phenoxy)-5-methylpyrimidin-4-yloxy)piperidin-1-yl)-3-isopropyl-1,2,4-oxadiazole
• CAS No.: 1258604-36-2
• Molecular Formula: C₂₇H₃₅N₅O₅
• Molecular Weight: 509.605
• Mol file: 1258604-36-2.mol

Synonyms:5-(4-(6-(4-(2,2-dimethyl-1,3-dioxan-5-yl)phenoxy)-5-methylpyrimidin-4-yloxy)piperidin-1-yl)-3-isopropyl-1,2,4-oxadiazole

Chemical Property of 5-(4-(6-(4-(2,2-dimethyl-1,3-dioxan-5-yl)phenoxy)-5-methylpyrimidin-4-yloxy)piperidin-1-yl)-3-isopropyl-1,2,4-oxadiazole

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 5-(4-(6-(4-(2,2-dimethyl-1,3-dioxan-5-yl)phenoxy)-5-methylpyrimidin-4-yloxy)piperidin-1-yl)-3-isopropyl-1,2,4-oxadiazole

There total 6 articles about 5-(4-(6-(4-(2,2-dimethyl-1,3-dioxan-5-yl)phenoxy)-5-methylpyrimidin-4-yloxy)piperidin-1-yl)-3-isopropyl-1,2,4-oxadiazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-chloro-6-[1-(3-isopropyl-[1,2,4]oxadiazol-5-yl)-piperidin-4-yloxy]-5-methyl-pyrimidine (832753-93-2) + 4-(2,2-dimethyl-1,3-dioxan-5-yl)phenol (1258604-31-7) → 5-(4-(6-(4-(2,2-dimethyl-1,3-dioxan-5-yl)phenoxy)-5-methylpyrimidin-4-yloxy)piperidin-1-yl)-3-isopropyl-1,2,4-oxadiazole (1258604-36-2)

Guidance literature:

With caesium carbonate; In N,N-dimethyl-formamide; at 80 ℃; for 3h;

Reference yield:

2-<4-(phenylmethoxy)phenyl>acetic acid ethyl ester (56441-69-1) → 5-(4-(6-(4-(2,2-dimethyl-1,3-dioxan-5-yl)phenoxy)-5-methylpyrimidin-4-yloxy)piperidin-1-yl)-3-isopropyl-1,2,4-oxadiazole (1258604-36-2)

Guidance literature:

Multi-step reaction with 5 steps

1.1: sodium hydride / THF (tetrahydrofuran) / 19 h / 0 - 30 °C

2.1: sodium tetrahydroborate / ethanol / 4 h / 0 - 30 °C

2.2: Cooling with ice

3.1: toluene-4-sulfonic acid / toluene / 18 h / 30 °C

4.1: ammonium formate / palladium 10% on activated carbon / methanol / 2 h / Reflux

5.1: caesium carbonate / N,N-dimethyl-formamide / 3 h / 80 °C

With sodium tetrahydroborate; ammonium formate; sodium hydride; caesium carbonate; palladium 10% on activated carbon; toluene-4-sulfonic acid; In methanol; ethanol; N,N-dimethyl-formamide; toluene;

Reference yield:

diethyl 2-(4'-benzyloxyphenyl)malonate (24220-48-2) → 5-(4-(6-(4-(2,2-dimethyl-1,3-dioxan-5-yl)phenoxy)-5-methylpyrimidin-4-yloxy)piperidin-1-yl)-3-isopropyl-1,2,4-oxadiazole (1258604-36-2)

Guidance literature:

Multi-step reaction with 4 steps

1.1: sodium tetrahydroborate / ethanol / 4 h / 0 - 30 °C

1.2: Cooling with ice

2.1: toluene-4-sulfonic acid / toluene / 18 h / 30 °C

3.1: ammonium formate / palladium 10% on activated carbon / methanol / 2 h / Reflux

4.1: caesium carbonate / N,N-dimethyl-formamide / 3 h / 80 °C

With sodium tetrahydroborate; ammonium formate; caesium carbonate; palladium 10% on activated carbon; toluene-4-sulfonic acid; In methanol; ethanol; N,N-dimethyl-formamide; toluene;

upstream raw materials:

4-chloro-6-[1-(3-isopropyl-[1,2,4]oxadiazol-5-yl)-piperidin-4-yloxy]-5-methyl-pyrimidine

4-(2,2-dimethyl-1,3-dioxan-5-yl)phenol

2-<4-(phenylmethoxy)phenyl>acetic acid ethyl ester

1-[3-(propan-2-yl)-1,2,4-oxadiazol-5-yl]piperidin-4-ol

Downstream raw materials:

2-(4-(6-(1-(3-isopropyl-1,2,4-oxadiazol-5-yl)piperidin-4-yloxy)-5-methylpyrimidin-4-yloxy)phenyl)propane-1,3-diol