(1R,2 S)-2-[(1-Ethyl-3-methyl-1H-pyrazol-4-yl)oxymethyl]-2-(3-fluorophenyl)cyclopropanecarbaldehyde

Base Information

Chemical Name:(1R,2 S)-2-[(1-Ethyl-3-methyl-1H-pyrazol-4-yl)oxymethyl]-2-(3-fluorophenyl)cyclopropanecarbaldehyde
CAS No.:1383747-13-4
Molecular Formula:C₁₇H₁₉FN₂O₂
Molecular Weight:302.348
Hs Code.:

Synonyms:(1R,2 S)-2-[(1-Ethyl-3-methyl-1H-pyrazol-4-yl)oxymethyl]-2-(3-fluorophenyl)cyclopropanecarbaldehyde

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Chemical Property of (1R,2 S)-2-[(1-Ethyl-3-methyl-1H-pyrazol-4-yl)oxymethyl]-2-(3-fluorophenyl)cyclopropanecarbaldehyde

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Technology Process of (1R,2 S)-2-[(1-Ethyl-3-methyl-1H-pyrazol-4-yl)oxymethyl]-2-(3-fluorophenyl)cyclopropanecarbaldehyde

There total 7 articles about (1R,2 S)-2-[(1-Ethyl-3-methyl-1H-pyrazol-4-yl)oxymethyl]-2-(3-fluorophenyl)cyclopropanecarbaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1383747-12-3
{(1R,2S)-2-[(1-Ethyl-3-methyl-1H-pyrazol-4-yl)oxymethyl]-2-(3-fluorophenyl)cyclopropyl}methanol

: 1383747-13-4
(1R,2 S)-2-[(1-Ethyl-3-methyl-1H-pyrazol-4-yl)oxymethyl]-2-(3-fluorophenyl)cyclopropanecarbaldehyde

Guidance literature:: {(1R,2S)-2-[(1-Ethyl-3-methyl-1H-pyrazol-4-yl)oxymethyl]-2-(3-fluorophenyl)cyclopropyl}methanol; With oxalyl dichloride; dimethyl sulfoxide; In dichloromethane; at -78 ℃; for 1h;

With triethylamine; In dichloromethane; at 10 - 35 ℃; for 0.833333h;

Reference yield:

: 501-00-8
3-fluorophenylacetonitrile

: 1383747-13-4
(1R,2 S)-2-[(1-Ethyl-3-methyl-1H-pyrazol-4-yl)oxymethyl]-2-(3-fluorophenyl)cyclopropanecarbaldehyde

Guidance literature:: Multi-step reaction with 6 steps

1.1: sodium hexamethyldisilazane / tetrahydrofuran / 1 h / Cooling with ice-salt

1.2: 16 h / 0 - 35 °C

2.1: sodium tetrahydroborate / tetrahydrofuran; methanol / 65 h / 0 - 35 °C

2.2: Cooling with ice

3.1: triethylamine / dichloromethane / 21.5 h / -20 - 35 °C

4.1: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 20 h / 0 - 35 °C

5.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 18 h / 10 - 35 °C

6.1: oxalyl dichloride; dimethyl sulfoxide / dichloromethane / 1 h / -78 °C

6.2: 0.83 h / 10 - 35 °C

With sodium tetrahydroborate; oxalyl dichloride; di-isopropyl azodicarboxylate; tetrabutyl ammonium fluoride; sodium hexamethyldisilazane; dimethyl sulfoxide; triethylamine; triphenylphosphine; In tetrahydrofuran; methanol; dichloromethane; 4.1: Mitsunobu reaction / 6.1: Swern Oxidation;

Reference yield:

: 1383746-99-3
1-ethyl-3-methyl-1H-pyrazol-4-ol

: 1383747-13-4
(1R,2 S)-2-[(1-Ethyl-3-methyl-1H-pyrazol-4-yl)oxymethyl]-2-(3-fluorophenyl)cyclopropanecarbaldehyde

Guidance literature:: Multi-step reaction with 3 steps

1.1: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 20 h / 0 - 35 °C

2.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 18 h / 10 - 35 °C

3.1: oxalyl dichloride; dimethyl sulfoxide / dichloromethane / 1 h / -78 °C

3.2: 0.83 h / 10 - 35 °C

With oxalyl dichloride; di-isopropyl azodicarboxylate; tetrabutyl ammonium fluoride; dimethyl sulfoxide; triphenylphosphine; In tetrahydrofuran; dichloromethane; 1.1: Mitsunobu reaction / 3.1: Swern Oxidation;