{(1R,2S)-2-[(1-Ethyl-3-methyl-1H-pyrazol-4-yl)oxymethyl]-2-(3-fluorophenyl)cyclopropyl}methanol

Base Information

Chemical Name:{(1R,2S)-2-[(1-Ethyl-3-methyl-1H-pyrazol-4-yl)oxymethyl]-2-(3-fluorophenyl)cyclopropyl}methanol
CAS No.:1383747-12-3
Molecular Formula:C₁₇H₂₁FN₂O₂
Molecular Weight:304.364
Hs Code.:

Synonyms:{(1R,2S)-2-[(1-Ethyl-3-methyl-1H-pyrazol-4-yl)oxymethyl]-2-(3-fluorophenyl)cyclopropyl}methanol

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Chemical Property of {(1R,2S)-2-[(1-Ethyl-3-methyl-1H-pyrazol-4-yl)oxymethyl]-2-(3-fluorophenyl)cyclopropyl}methanol

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Technology Process of {(1R,2S)-2-[(1-Ethyl-3-methyl-1H-pyrazol-4-yl)oxymethyl]-2-(3-fluorophenyl)cyclopropyl}methanol

There total 6 articles about {(1R,2S)-2-[(1-Ethyl-3-methyl-1H-pyrazol-4-yl)oxymethyl]-2-(3-fluorophenyl)cyclopropyl}methanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1383747-11-2
4-{[(1S,2R)-2-(tert-Butyldiphenylsilyloxymethyl)-1-(3-fluorophenyl)cyclopropyl]methoxy}-1-ethyl-3-methyl-1H-pyrazole

: 1383747-12-3
{(1R,2S)-2-[(1-Ethyl-3-methyl-1H-pyrazol-4-yl)oxymethyl]-2-(3-fluorophenyl)cyclopropyl}methanol

Guidance literature:: With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 10 - 35 ℃; for 18h;

Reference yield:

: 501-00-8
3-fluorophenylacetonitrile

: 1383747-12-3
{(1R,2S)-2-[(1-Ethyl-3-methyl-1H-pyrazol-4-yl)oxymethyl]-2-(3-fluorophenyl)cyclopropyl}methanol

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium hexamethyldisilazane / tetrahydrofuran / 1 h / Cooling with ice-salt

1.2: 16 h / 0 - 35 °C

2.1: sodium tetrahydroborate / tetrahydrofuran; methanol / 65 h / 0 - 35 °C

2.2: Cooling with ice

3.1: triethylamine / dichloromethane / 21.5 h / -20 - 35 °C

4.1: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 20 h / 0 - 35 °C

5.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 18 h / 10 - 35 °C

With sodium tetrahydroborate; di-isopropyl azodicarboxylate; tetrabutyl ammonium fluoride; sodium hexamethyldisilazane; triethylamine; triphenylphosphine; In tetrahydrofuran; methanol; dichloromethane; 4.1: Mitsunobu reaction;

Reference yield:

: 1383746-99-3
1-ethyl-3-methyl-1H-pyrazol-4-ol

: 1383747-12-3
{(1R,2S)-2-[(1-Ethyl-3-methyl-1H-pyrazol-4-yl)oxymethyl]-2-(3-fluorophenyl)cyclopropyl}methanol

Guidance literature:: Multi-step reaction with 2 steps

1: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 20 h / 0 - 35 °C

2: tetrabutyl ammonium fluoride / tetrahydrofuran / 18 h / 10 - 35 °C

With di-isopropyl azodicarboxylate; tetrabutyl ammonium fluoride; triphenylphosphine; In tetrahydrofuran; 1: Mitsunobu reaction;