methyl (R)-N-(tert-butoxycarbonyl)-2-(3-bromo-4-methoxyphenyl)glycinate

Base Information

• Chemical Name: methyl (R)-N-(tert-butoxycarbonyl)-2-(3-bromo-4-methoxyphenyl)glycinate
• CAS No.: 192328-47-5
• Molecular Formula: C₁₅H₂₀BrNO₅
• Molecular Weight: 374.232

Synonyms:methyl (R)-N-(tert-butoxycarbonyl)-2-(3-bromo-4-methoxyphenyl)glycinate

Chemical Property of methyl (R)-N-(tert-butoxycarbonyl)-2-(3-bromo-4-methoxyphenyl)glycinate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of methyl (R)-N-(tert-butoxycarbonyl)-2-(3-bromo-4-methoxyphenyl)glycinate

There total 7 articles about methyl (R)-N-(tert-butoxycarbonyl)-2-(3-bromo-4-methoxyphenyl)glycinate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

(R)-(3-Bromo-4-methoxy-phenyl)-tert-butoxycarbonylamino-acetic acid (174146-44-2) + diazomethyl-trimethyl-silane (18107-18-1) → methyl (R)-N-(tert-butoxycarbonyl)-2-(3-bromo-4-methoxyphenyl)glycinate (192328-47-5)

Guidance literature:

In methanol; benzene; at 80 ℃;

DOI:10.1021/jo970560p

Reference yield: 72.0%

(2R)-2-(3-bromo-4-hydroxyphenyl)-2-[(2-methylpropan-2-yl)oxycarbonylamino]acetic acid (139517-62-7) + methyl iodide (74-88-4) → methyl (R)-N-(tert-butoxycarbonyl)-2-(3-bromo-4-methoxyphenyl)glycinate (192328-47-5)

Guidance literature:

With caesium carbonate; In N,N-dimethyl-formamide; at 20 ℃; for 18h;

DOI:10.1021/jo0621266

Reference yield:

(2R)-2-(3-bromo-4-hydroxyphenyl)-2-[(2-methylpropan-2-yl)oxycarbonylamino]acetic acid (139517-62-7) → methyl (R)-N-(tert-butoxycarbonyl)-2-(3-bromo-4-methoxyphenyl)glycinate (192328-47-5)

Guidance literature:

Multi-step reaction with 2 steps

1: 70 percent / NaH / tetrahydrofuran; dimethylformamide / 0.25 h / 0 °C

2: 100 percent / benzene; methanol / 80 °C

With sodium hydride; In tetrahydrofuran; methanol; N,N-dimethyl-formamide; benzene;

DOI:10.1021/jo970560p

upstream raw materials:

(R)-(3-Bromo-4-methoxy-phenyl)-tert-butoxycarbonylamino-acetic acid

diazomethyl-trimethyl-silane

(2R)-2-(3-bromo-4-hydroxyphenyl)-2-[(2-methylpropan-2-yl)oxycarbonylamino]acetic acid

methyl iodide

Downstream raw materials:

(R)-Amino-(3-bromo-4-methoxy-phenyl)-acetic acid methyl ester

(R)-(3-Bromo-4-methoxy-phenyl)-[(R)-2-tert-butoxycarbonylamino-2-(3,5-dihydroxy-4-methoxy-phenyl)-acetylamino]-acetic acid

(R)-(3-Bromo-4-methoxy-phenyl)-[(R)-2-tert-butoxycarbonylamino-2-(3,5-dihydroxy-4-methoxy-phenyl)-acetylamino]-acetic acid methyl ester

C₃₉H₅₀BrN₃O₁₁Si

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 192328-47-5 methyl (R)-N-(tert-butoxycarbonyl)-2-(3-bromo-4-methoxyphenyl)glycinate

Send

Send

Metric Ton KG G Pound L ML

Send

Send