sodium (2R,3R)-3-hydroxy-3-(4-{[(E)-(6-oxocyclohexa-2,4-dien-1-ylidene)methyl]amino}phenyl)-2-[(phenylacetyl)amino]propanoate

Base Information

• Chemical Name: sodium (2R,3R)-3-hydroxy-3-(4-{[(E)-(6-oxocyclohexa-2,4-dien-1-ylidene)methyl]amino}phenyl)-2-[(phenylacetyl)amino]propanoate
• CAS No.: 117490-92-3
• Molecular Formula: C₂₄H₂₁N₂O₅*Na
• Molecular Weight: 440.431
• Mol file: 117490-92-3.mol

Synonyms:DL-Phenylalanine,b-hydroxy-4-[[(2-hydroxyphenyl)methylene]amino]-N-(phenylacetyl)-,sodium salt, erythro-

Chemical Property of sodium (2R,3R)-3-hydroxy-3-(4-{[(E)-(6-oxocyclohexa-2,4-dien-1-ylidene)methyl]amino}phenyl)-2-[(phenylacetyl)amino]propanoate

Chemical Property:

• Vapor Pressure: 5.04E-23mmHg at 25°C
• Boiling Point: 740.5°Cat760mmHg
• Flash Point: 401.6°C
• Density: g/cm³

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of sodium (2R,3R)-3-hydroxy-3-(4-{[(E)-(6-oxocyclohexa-2,4-dien-1-ylidene)methyl]amino}phenyl)-2-[(phenylacetyl)amino]propanoate

There total 4 articles about sodium (2R,3R)-3-hydroxy-3-(4-{[(E)-(6-oxocyclohexa-2,4-dien-1-ylidene)methyl]amino}phenyl)-2-[(phenylacetyl)amino]propanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(2RS,3RS)-2-amino-3-hydroxy-3-(4-nitro-phenyl)-propionic acid (5872-74-2,5872-75-3,10098-38-1,17580-62-0,28908-09-0,50730-77-3,110772-43-5,119934-01-9,129446-45-3,135635-69-7) → Nα-Phenylacetyl-p-salicylidene-erythro-DL-phenylserine sodium salt (117490-92-3)

Guidance literature:

Multi-step reaction with 3 steps

1: 77 percent / 1.84N NaOH / diethyl ether; H₂O / 2 h

2: H₂, 2.296N NaOCH₃ / palladium black / methanol / 40 - 45 °C

3: methanol

With sodium hydroxide; hydrogen; sodium methylate; palladium; In methanol; diethyl ether; water;

DOI:10.1007/BF00763631

Reference yield:

Nα-Phenylacetyl-p-nitro-erythro-DL-phenylserine (117490-94-5) → Nα-Phenylacetyl-p-salicylidene-erythro-DL-phenylserine sodium salt (117490-92-3)

Guidance literature:

Multi-step reaction with 2 steps

1: H₂, 2.296N NaOCH₃ / palladium black / methanol / 40 - 45 °C

2: methanol

With hydrogen; sodium methylate; palladium; In methanol;

DOI:10.1007/BF00763631

Reference yield:

phenylacetyl chloride (103-80-0) → Nα-Phenylacetyl-p-salicylidene-erythro-DL-phenylserine sodium salt (117490-92-3)

Guidance literature:

Multi-step reaction with 3 steps

1: 77 percent / 1.84N NaOH / diethyl ether; H₂O / 2 h

2: H₂, 2.296N NaOCH₃ / palladium black / methanol / 40 - 45 °C

3: methanol

With sodium hydroxide; hydrogen; sodium methylate; palladium; In methanol; diethyl ether; water;

DOI:10.1007/BF00763631

upstream raw materials:

salicylaldehyde

Sodium; (2S,3S)-3-(4-amino-phenyl)-3-hydroxy-2-phenylacetylamino-propionate

(2RS,3RS)-2-amino-3-hydroxy-3-(4-nitro-phenyl)-propionic acid

N^α-Phenylacetyl-p-nitro-erythro-DL-phenylserine