1-methyl-3,4,6-triphenylisoquinoline

Base Information

• Chemical Name: 1-methyl-3,4,6-triphenylisoquinoline
• CAS No.: 1257846-35-7
• Molecular Formula: C₂₈H₂₁N
• Molecular Weight: 371.481
• Mol file: 1257846-35-7.mol

Synonyms:1-methyl-3,4,6-triphenylisoquinoline

Chemical Property of 1-methyl-3,4,6-triphenylisoquinoline

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-methyl-3,4,6-triphenylisoquinoline

There total 11 articles about 1-methyl-3,4,6-triphenylisoquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

4-acetylbiphenyl oxime (75408-89-8) + diphenyl acetylene (501-65-5) → 1-methyl-3,4,6-triphenylisoquinoline (1257846-35-7)

Guidance literature:

With bis[dichloro(pentamethylcyclopentadienyl)iridium(III)]; Trimethylacetic acid; In methanol; at 100 ℃; for 24h; regioselective reaction; Sealed tube;

DOI:10.1016/j.tet.2019.04.039

Reference yield: 94.0%

→ 1-methyl-3,4,6-triphenylisoquinoline (1257846-35-7)

Guidance literature:

With bis[dichloro(pentamethylcyclopentadienyl)iridium(III)]; Trimethylacetic acid; In methanol; at 60 ℃; for 24h;

Reference yield: 93.0%

4-Phenyl-acetophenon-dimethylhydrazon (5758-00-9) + diphenyl acetylene (501-65-5) → 1-methyl-3,4,6-triphenylisoquinoline (1257846-35-7)

Guidance literature:

With dichloro(pentamethylcyclopentadienyl)rhodium (III) dimer; acetic acid; In methanol; at 90 ℃; Inert atmosphere; Sealed tube; Schlenk technique;

DOI:10.1021/ol402796m

upstream raw materials:

biphenyl-4-acetaldehyde

(E)-1-[(1,1'-biphenyl)-4-yl]ethanone O-acetyl oxime

diphenyl acetylene

4-acetylbiphenyl oxime