(NZ)-N-[1-(4-phenylphenyl)ethylidene]hydroxylamine

Base Information

• Chemical Name: (NZ)-N-[1-(4-phenylphenyl)ethylidene]hydroxylamine
• CAS No.: 75408-89-8
• Molecular Formula: C₁₄H₁₃NO
• Molecular Weight: 211.263
• DSSTox Substance ID: DTXSID00442087
• Nikkaji Number: J1.008.107F
• Wikidata: Q82259169
• Mol file: 75408-89-8.mol

Synonyms:DTXSID00442087;SBB057521;AKOS000280109

Chemical Property of (NZ)-N-[1-(4-phenylphenyl)ethylidene]hydroxylamine

Chemical Property:

• Melting Point: 186 °C
• Boiling Point: 370.1±21.0 °C(Predicted)
• Density: 1.04±0.1 g/cm3(Predicted)
• XLogP3: 3.5
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 2
• Exact Mass: 211.099714038
• Heavy Atom Count: 16
• Complexity: 235

Purity/Quality:

97% ^*data from raw suppliers

4-Acetylbiphenyloxime 90% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: CC(=NO)C1=CC=C(C=C1)C2=CC=CC=C2
• Isomeric SMILES: C/C(=N/O)/C1=CC=C(C=C1)C2=CC=CC=C2
• Uses: 4-Acetylbiphenyl Oxime is a useful intermediate in the synthesis of various pharmaceutically and biologically active compounds like bis-oximinoalkanoic acids as potent PPARα agonists.

Technology Process of (NZ)-N-[1-(4-phenylphenyl)ethylidene]hydroxylamine

There total 7 articles about (NZ)-N-[1-(4-phenylphenyl)ethylidene]hydroxylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

biphenyl-4-acetaldehyde (92-91-1) → 4-acetylbiphenyl oxime (75408-89-8)

Guidance literature:

With hydroxylamine hydrochloride; sodium acetate; In ethanol; water; Reflux;

DOI:10.1021/acs.orglett.5b03462

Reference yield: 97.0%

biphenyl-4-acetaldehyde (92-91-1) → (E)-1-([1,1'-biphenyl]-4-yl)ethan-1-one oxime (75408-89-8)

Guidance literature:

With hydroxylamine hydrochloride; sodium hydroxide; In ethanol; water; at 20 ℃; for 24h; pH=9; Cooling with ice;

DOI:10.1016/j.tet.2019.02.032

Reference yield: 83.0%

C17H15N3O → 4-acetylbiphenyl oxime (75408-89-8)

Guidance literature:

With hydroxylamine hydrochloride; sodium acetate; In ethanol; for 6h; Reflux;

DOI:10.1080/00397911.2019.1655578

upstream raw materials:

biphenyl-4-acetaldehyde

pyridine

ethanol

Downstream raw materials:

biphenyl-4-acetaldehyde

1-phenylaminocarbonyloxyimino-1-(4-biphenyl)ethane

1-(1-naphthylaminocarbonyloxyimino)-1-(4-biphenyl)ethane

1-methyl-3,4,6-triphenylisoquinoline