Technology Process of 1,3,5-tri((3,4-dibutoxy)phenylmethyl)benzene
There total 4 articles about 1,3,5-tri((3,4-dibutoxy)phenylmethyl)benzene which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
3,4-dibutoxyphenylboronic acid;
With
sodium carbonate;
In
water; acetone;
at 20 ℃;
Inert atmosphere;
Cooling with ice;
1,3,5-Tris(bromomethyl)benzene;
With
palladium dichloride;
In
water; acetone;
at 0 - 38 ℃;
for 84h;
Inert atmosphere;
DOI:10.1021/ja413018f
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: Triisopropyl borate; n-butyllithium / tetrahydrofuran; hexane / 2 h / -80 °C / Inert atmosphere
2.1: sodium carbonate / water; acetone / 20 °C / Inert atmosphere; Cooling with ice
2.2: 84 h / 0 - 38 °C / Inert atmosphere
With
n-butyllithium; Triisopropyl borate; sodium carbonate;
In
tetrahydrofuran; hexane; water; acetone;
2.2: |Suzuki Coupling;
DOI:10.1021/ja413018f
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: N-Bromosuccinimide; silica gel / dichloromethane / 8 h / 20 °C
2.1: Triisopropyl borate; n-butyllithium / tetrahydrofuran; hexane / 2 h / -80 °C / Inert atmosphere
3.1: sodium carbonate / water; acetone / 20 °C / Inert atmosphere; Cooling with ice
3.2: 84 h / 0 - 38 °C / Inert atmosphere
With
N-Bromosuccinimide; n-butyllithium; Triisopropyl borate; silica gel; sodium carbonate;
In
tetrahydrofuran; hexane; dichloromethane; water; acetone;
3.2: |Suzuki Coupling;
DOI:10.1021/ja413018f
