(S)-4-(4-(4-(benzyloxycarbonylamino)but-1-ynyl)naphthalen-1-yl)-2-(tert-butoxycarbonylamino)butanoic acid

Base Information

Chemical Name:(S)-4-(4-(4-(benzyloxycarbonylamino)but-1-ynyl)naphthalen-1-yl)-2-(tert-butoxycarbonylamino)butanoic acid
CAS No.:1613625-01-6
Molecular Formula:C₃₁H₃₄N₂O₆
Molecular Weight:530.621
Hs Code.:

Synonyms:(S)-4-(4-(4-(benzyloxycarbonylamino)but-1-ynyl)naphthalen-1-yl)-2-(tert-butoxycarbonylamino)butanoic acid

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Chemical Property of (S)-4-(4-(4-(benzyloxycarbonylamino)but-1-ynyl)naphthalen-1-yl)-2-(tert-butoxycarbonylamino)butanoic acid

Chemical Property:

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Technology Process of (S)-4-(4-(4-(benzyloxycarbonylamino)but-1-ynyl)naphthalen-1-yl)-2-(tert-butoxycarbonylamino)butanoic acid

There total 10 articles about (S)-4-(4-(4-(benzyloxycarbonylamino)but-1-ynyl)naphthalen-1-yl)-2-(tert-butoxycarbonylamino)butanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1613625-00-5
(S)-methyl 4-(4-(4-(benzyloxycarbonylamino)but-1-ynyl)naphthalen-1-yl)-2-(tert-butoxycarbonylamino)butanoate

: 1613625-01-6
(S)-4-(4-(4-(benzyloxycarbonylamino)but-1-ynyl)naphthalen-1-yl)-2-(tert-butoxycarbonylamino)butanoic acid

Guidance literature:: With water; sodium hydroxide; In tetrahydrofuran; methanol; at 20 ℃; for 3h;

Reference yield:

: 10465-20-0
γ-(4-methoxy-1-naphthyl)butyric acid

: 1613625-01-6
(S)-4-(4-(4-(benzyloxycarbonylamino)but-1-ynyl)naphthalen-1-yl)-2-(tert-butoxycarbonylamino)butanoic acid

Guidance literature:: Multi-step reaction with 10 steps

1.1: n-butyllithium / tetrahydrofuran / 0.75 h / -78 °C

1.2: 3.5 h / 0 - 20 °C

2.1: potassium hexamethylsilazane / tetrahydrofuran / 0.5 h / -78 °C

2.2: -78 °C

2.3: 16 h / -78 - 27 °C

3.1: dihydrogen peroxide; lithium hydroxide / tetrahydrofuran; water / 3 h / 0 °C

4.1: hydrogen; palladium 10% on activated carbon / water / 3 h / 20 °C / 760.05 Torr

5.1: acetic acid; hydrogen bromide / 4 h / Reflux

6.1: acetyl chloride / 4 h / 0 °C / Reflux

7.1: sodium hydrogencarbonate / methanol; water / 3 h / 0 - 20 °C

8.1: pyridine / 2.5 h / 0 - 20 °C

9.1: tri-tert-butyl phosphine; copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; triethylamine / acetonitrile; hexane / 5 h / Inert atmosphere; Reflux

10.1: sodium hydroxide; water / tetrahydrofuran; methanol / 3 h / 20 °C

With pyridine; copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; n-butyllithium; tri-tert-butyl phosphine; palladium 10% on activated carbon; water; hydrogen bromide; hydrogen; dihydrogen peroxide; potassium hexamethylsilazane; sodium hydrogencarbonate; acetic acid; triethylamine; acetyl chloride; sodium hydroxide; lithium hydroxide; In tetrahydrofuran; methanol; hexane; water; acetonitrile;

Reference yield:

: 1613624-91-1
(S)-4-benzyl-3-(4-(4-methoxynaphthalen-1-yl)butanoyl)oxazolidin-2-one

: 1613625-01-6
(S)-4-(4-(4-(benzyloxycarbonylamino)but-1-ynyl)naphthalen-1-yl)-2-(tert-butoxycarbonylamino)butanoic acid

Guidance literature:: Multi-step reaction with 9 steps

1.1: potassium hexamethylsilazane / tetrahydrofuran / 0.5 h / -78 °C

1.2: -78 °C

1.3: 16 h / -78 - 27 °C

2.1: dihydrogen peroxide; lithium hydroxide / tetrahydrofuran; water / 3 h / 0 °C

3.1: hydrogen; palladium 10% on activated carbon / water / 3 h / 20 °C / 760.05 Torr

4.1: acetic acid; hydrogen bromide / 4 h / Reflux

5.1: acetyl chloride / 4 h / 0 °C / Reflux

6.1: sodium hydrogencarbonate / methanol; water / 3 h / 0 - 20 °C

7.1: pyridine / 2.5 h / 0 - 20 °C

8.1: tri-tert-butyl phosphine; copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; triethylamine / acetonitrile; hexane / 5 h / Inert atmosphere; Reflux

9.1: sodium hydroxide; water / tetrahydrofuran; methanol / 3 h / 20 °C

With pyridine; copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; tri-tert-butyl phosphine; palladium 10% on activated carbon; water; hydrogen bromide; hydrogen; dihydrogen peroxide; potassium hexamethylsilazane; sodium hydrogencarbonate; acetic acid; triethylamine; acetyl chloride; sodium hydroxide; lithium hydroxide; In tetrahydrofuran; methanol; hexane; water; acetonitrile;