(R/S)-N-((1H-imidazol-2-yl)methyl)-3-(2-hydroxy-2-(4-(5-(3-phenyl-4-(trifluoromethyl)isoxazol-5-yl)-1,2,4-oxadiazol-3-yl)phenyl)acetamido)propanamide trifluoroacetate

Base Information

Chemical Name:(R/S)-N-((1H-imidazol-2-yl)methyl)-3-(2-hydroxy-2-(4-(5-(3-phenyl-4-(trifluoromethyl)isoxazol-5-yl)-1,2,4-oxadiazol-3-yl)phenyl)acetamido)propanamide trifluoroacetate
CAS No.:1344707-22-7
Molecular Formula:C₂HF₃O₂*C₂₇H₂₂F₃N₇O₅
Molecular Weight:695.535
Hs Code.:

(R/S)-N-((1H-imidazol-2-yl)methyl)-3-(2-hydroxy-2-(4-(5-(3-phenyl-4-(trifluoromethyl)isoxazol-5-yl)-1,2,4-oxadiazol-3-yl)phenyl)acetamido)propanamide trifluoroacetate

Synonyms:(R/S)-N-((1H-imidazol-2-yl)methyl)-3-(2-hydroxy-2-(4-(5-(3-phenyl-4-(trifluoromethyl)isoxazol-5-yl)-1,2,4-oxadiazol-3-yl)phenyl)acetamido)propanamide trifluoroacetate

Suppliers and Price of (R/S)-N-((1H-imidazol-2-yl)methyl)-3-(2-hydroxy-2-(4-(5-(3-phenyl-4-(trifluoromethyl)isoxazol-5-yl)-1,2,4-oxadiazol-3-yl)phenyl)acetamido)propanamide trifluoroacetate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (R/S)-N-((1H-imidazol-2-yl)methyl)-3-(2-hydroxy-2-(4-(5-(3-phenyl-4-(trifluoromethyl)isoxazol-5-yl)-1,2,4-oxadiazol-3-yl)phenyl)acetamido)propanamide trifluoroacetate

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of (R/S)-N-((1H-imidazol-2-yl)methyl)-3-(2-hydroxy-2-(4-(5-(3-phenyl-4-(trifluoromethyl)isoxazol-5-yl)-1,2,4-oxadiazol-3-yl)phenyl)acetamido)propanamide trifluoroacetate

There total 12 articles about (R/S)-N-((1H-imidazol-2-yl)methyl)-3-(2-hydroxy-2-(4-(5-(3-phenyl-4-(trifluoromethyl)isoxazol-5-yl)-1,2,4-oxadiazol-3-yl)phenyl)acetamido)propanamide trifluoroacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 2.86%

: 1344706-06-4
(R/S)-3-(2-hydroxy-2-(4-(5-(3-phenyl-4-(trifluoromethyl)isoxazol-5-yl)-1,2,4-oxadiazol-3-yl)phenyl)acetamido)propanoic acid

: 22600-77-7,138799-95-8
(1H-imidazol-2-yl)methanamine dihydrochloride

: 76-05-1
trifluoroacetic acid

: 1344707-22-7
(R/S)-N-((1H-imidazol-2-yl)methyl)-3-(2-hydroxy-2-(4-(5-(3-phenyl-4-(trifluoromethyl)isoxazol-5-yl)-1,2,4-oxadiazol-3-yl)phenyl)acetamido)propanamide trifluoroacetate

Guidance literature:: (R/S)-3-(2-hydroxy-2-(4-(5-(3-phenyl-4-(trifluoromethyl)isoxazol-5-yl)-1,2,4-oxadiazol-3-yl)phenyl)acetamido)propanoic acid; (1H-imidazol-2-yl)methanamine dihydrochloride; With 4-methyl-morpholine; HATU; In N,N-dimethyl-formamide; for 1h;

trifluoroacetic acid; In methanol; water;

Reference yield:

: 932-90-1,622-31-1,140461-24-1,140461-25-2,622-32-2
syn-benzaldehyde oxime

: 1344707-22-7
(R/S)-N-((1H-imidazol-2-yl)methyl)-3-(2-hydroxy-2-(4-(5-(3-phenyl-4-(trifluoromethyl)isoxazol-5-yl)-1,2,4-oxadiazol-3-yl)phenyl)acetamido)propanamide trifluoroacetate

Guidance literature:: Multi-step reaction with 9 steps

1.1: N-chloro-succinimide / N,N-dimethyl-formamide / 20 °C

2.1: triethylamine / 1,2-dichloro-ethane / 20 - 70 °C

3.1: Jones reagent / acetone / 20 °C

4.1: pyridine; trifluoro-[1,3,5]triazine / dichloromethane / 20 °C

5.1: N-ethyl-N,N-diisopropylamine / acetonitrile

6.1: water; lithium hydroxide / tetrahydrofuran; methanol / 1 h / 0 °C

7.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; 4-methyl-morpholine / N,N-dimethyl-formamide

8.1: trifluoroacetic acid / dichloromethane / 1 h

9.1: 4-methyl-morpholine; HATU / N,N-dimethyl-formamide / 1 h

9.2: PHENOMENEX_.(R). Luna 5u

With 4-methyl-morpholine; pyridine; N-chloro-succinimide; Jones reagent; trifluoro-[1,3,5]triazine; water; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; N-ethyl-N,N-diisopropylamine; HATU; trifluoroacetic acid; lithium hydroxide; In tetrahydrofuran; methanol; dichloromethane; 1,2-dichloro-ethane; N,N-dimethyl-formamide; acetone; acetonitrile;

Reference yield:

: 934-16-7
phenylhydroxamoyl chloride

: 1344707-22-7
(R/S)-N-((1H-imidazol-2-yl)methyl)-3-(2-hydroxy-2-(4-(5-(3-phenyl-4-(trifluoromethyl)isoxazol-5-yl)-1,2,4-oxadiazol-3-yl)phenyl)acetamido)propanamide trifluoroacetate

Guidance literature:: Multi-step reaction with 8 steps

1.1: triethylamine / 1,2-dichloro-ethane / 20 - 70 °C

2.1: Jones reagent / acetone / 20 °C

3.1: pyridine; trifluoro-[1,3,5]triazine / dichloromethane / 20 °C

4.1: N-ethyl-N,N-diisopropylamine / acetonitrile

5.1: water; lithium hydroxide / tetrahydrofuran; methanol / 1 h / 0 °C

6.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; 4-methyl-morpholine / N,N-dimethyl-formamide

7.1: trifluoroacetic acid / dichloromethane / 1 h

8.1: 4-methyl-morpholine; HATU / N,N-dimethyl-formamide / 1 h

8.2: PHENOMENEX_.(R). Luna 5u

With 4-methyl-morpholine; pyridine; Jones reagent; trifluoro-[1,3,5]triazine; water; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; N-ethyl-N,N-diisopropylamine; HATU; trifluoroacetic acid; lithium hydroxide; In tetrahydrofuran; methanol; dichloromethane; 1,2-dichloro-ethane; N,N-dimethyl-formamide; acetone; acetonitrile;