4-ethyl-N₂-{1-[trans-4-(propyloxy)cyclohexyl]-4-piperidinyl}-1,2-benzenediamine

Base Information

Chemical Name:4-ethyl-N₂-{1-[trans-4-(propyloxy)cyclohexyl]-4-piperidinyl}-1,2-benzenediamine
CAS No.:950772-58-4
Molecular Formula:C₂₂H₃₇N₃O
Molecular Weight:359.555
Hs Code.:

4-ethyl-N<sub>2</sub>-{1-[trans-4-(propyloxy)cyclohexyl]-4-piperidinyl}-1,2-benzenediamine

Synonyms:4-ethyl-N₂-{1-[trans-4-(propyloxy)cyclohexyl]-4-piperidinyl}-1,2-benzenediamine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 4-ethyl-N₂-{1-[trans-4-(propyloxy)cyclohexyl]-4-piperidinyl}-1,2-benzenediamine

Chemical Property:

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Technology Process of 4-ethyl-N₂-{1-[trans-4-(propyloxy)cyclohexyl]-4-piperidinyl}-1,2-benzenediamine

There total 11 articles about 4-ethyl-N₂-{1-[trans-4-(propyloxy)cyclohexyl]-4-piperidinyl}-1,2-benzenediamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: 950772-57-3
N-(5-ethenyl-2-nitrophenyl)-1-[trans-4-(propyloxy)cyclohexyl]-4-piperidinamine

: 950772-58-4
4-ethyl-N₂-{1-[trans-4-(propyloxy)cyclohexyl]-4-piperidinyl}-1,2-benzenediamine

Guidance literature:: With ammonium formate; palladium 10% on activated carbon; In methanol; at 20 ℃; for 0.666667h;

Reference yield:

: 3612-18-8
N-ethyl-4-piperidone

: 950772-58-4
4-ethyl-N₂-{1-[trans-4-(propyloxy)cyclohexyl]-4-piperidinyl}-1,2-benzenediamine

Guidance literature:: Multi-step reaction with 6 steps

1: acetone / 3 h / 0 - 30 °C

2: potassium carbonate / ethanol; water / 1 h / 80 °C / Heating / reflux

3: ammonia; hydrogen / palladium 10% on activated carbon / methanol / 18 h / 20 °C / 2585.81 Torr

4: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 5 h / 20 - 90 °C

5: triphenylphosphine / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / toluene / 20 - 120 °C

6: ammonium formate / palladium 10% on activated carbon / methanol / 0.67 h / 20 °C

With ammonia; hydrogen; ammonium formate; potassium carbonate; N-ethyl-N,N-diisopropylamine; triphenylphosphine; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; palladium 10% on activated carbon; In methanol; ethanol; water; N,N-dimethyl-formamide; acetone; toluene;

Reference yield:

: trans-4-hydroxycyclohexylamine hydrochloride

: 950772-58-4
4-ethyl-N₂-{1-[trans-4-(propyloxy)cyclohexyl]-4-piperidinyl}-1,2-benzenediamine

Guidance literature:: Multi-step reaction with 9 steps

1: potassium carbonate / water / 3 h / 20 °C

2: 1H-imidazole / N,N-dimethyl-formamide / 3 h / 20 - 40 °C

3: triethylsilane; bismuth(III) bromide / acetonitrile / 0.5 h / 0 - 30 °C

4: hydrazine / ethanol / 2 h / 80 °C

5: potassium carbonate / ethanol; water / 1 h / 80 °C / Heating / reflux

6: ammonia; hydrogen / palladium 10% on activated carbon / methanol / 18 h / 20 °C / 2585.81 Torr

7: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 5 h / 20 - 90 °C

8: triphenylphosphine / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / toluene / 20 - 120 °C

9: ammonium formate / palladium 10% on activated carbon / methanol / 0.67 h / 20 °C

With 1H-imidazole; triethylsilane; ammonia; hydrogen; ammonium formate; bismuth(III) bromide; potassium carbonate; N-ethyl-N,N-diisopropylamine; triphenylphosphine; hydrazine; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; palladium 10% on activated carbon; In methanol; ethanol; water; N,N-dimethyl-formamide; toluene; acetonitrile;