1-(2-(3-fluoro-4-(hydroxymethyl)phenylamino)-5-((2-(trimethylsilyl)ethoxy)methyl)-5H-pyrrolo [2,3-b]pyrazin-7-yl)-2,2-dimethylpropan-1-one

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Chemical Name:1-(2-(3-fluoro-4-(hydroxymethyl)phenylamino)-5-((2-(trimethylsilyl)ethoxy)methyl)-5H-pyrrolo [2,3-b]pyrazin-7-yl)-2,2-dimethylpropan-1-one
CAS No.:1413913-06-0
Molecular Formula:C₂₄H₃₃FN₄O₃Si
Molecular Weight:472.635
Hs Code.:

Synonyms:1-(2-(3-fluoro-4-(hydroxymethyl)phenylamino)-5-((2-(trimethylsilyl)ethoxy)methyl)-5H-pyrrolo [2,3-b]pyrazin-7-yl)-2,2-dimethylpropan-1-one

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Chemical Property of 1-(2-(3-fluoro-4-(hydroxymethyl)phenylamino)-5-((2-(trimethylsilyl)ethoxy)methyl)-5H-pyrrolo [2,3-b]pyrazin-7-yl)-2,2-dimethylpropan-1-one

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Technology Process of 1-(2-(3-fluoro-4-(hydroxymethyl)phenylamino)-5-((2-(trimethylsilyl)ethoxy)methyl)-5H-pyrrolo [2,3-b]pyrazin-7-yl)-2,2-dimethylpropan-1-one

There total 5 articles about 1-(2-(3-fluoro-4-(hydroxymethyl)phenylamino)-5-((2-(trimethylsilyl)ethoxy)methyl)-5H-pyrrolo [2,3-b]pyrazin-7-yl)-2,2-dimethylpropan-1-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1184852-50-3
1-(2-bromo-5-((2-(trimethylsilyl)ethoxy)methyl)-5H-pyrrolo[2,3-b]pyrazine-7-yl)-2,2-dimethylpropane-1-one

: 840501-15-7
(4-amino-2-fluorophenyl)methanol

: 1413913-06-0
1-(2-(3-fluoro-4-(hydroxymethyl)phenylamino)-5-((2-(trimethylsilyl)ethoxy)methyl)-5H-pyrrolo [2,3-b]pyrazin-7-yl)-2,2-dimethylpropan-1-one

Guidance literature:: 1-(2-bromo-5-((2-(trimethylsilyl)ethoxy)methyl)-5H-pyrrolo[2,3-b]pyrazine-7-yl)-2,2-dimethylpropane-1-one; (4-amino-2-fluorophenyl)methanol; With tris(dibenzylideneacetone)dipalladium⁽⁰⁾ chloroform complex; DavePhos; In 1,4-dioxane; for 0.166667h; Inert atmosphere;

With caesium carbonate; at 100 ℃; for 2h;

Reference yield:

: 73792-08-2
methyl 4-amino-2-fluorobenzoate

: 1413913-06-0
1-(2-(3-fluoro-4-(hydroxymethyl)phenylamino)-5-((2-(trimethylsilyl)ethoxy)methyl)-5H-pyrrolo [2,3-b]pyrazin-7-yl)-2,2-dimethylpropan-1-one

Guidance literature:: Multi-step reaction with 2 steps

1.1: tetrahydrofuran / 0.25 h / 0 - 5 °C / Inert atmosphere

1.2: 1.17 h / 20 °C

2.1: DavePhos; tris(dibenzylideneacetone)dipalladium⁽⁰⁾ chloroform complex / 1,4-dioxane / 0.17 h / Inert atmosphere

2.2: 2 h / 100 °C

With tris(dibenzylideneacetone)dipalladium⁽⁰⁾ chloroform complex; DavePhos; In tetrahydrofuran; 1,4-dioxane;

Reference yield:

: 875781-41-2
5-bromo-3-((trimethylsilyl)ethynyl)pyrazine-2-amine

: 1413913-06-0
1-(2-(3-fluoro-4-(hydroxymethyl)phenylamino)-5-((2-(trimethylsilyl)ethoxy)methyl)-5H-pyrrolo [2,3-b]pyrazin-7-yl)-2,2-dimethylpropan-1-one

Guidance literature:: Multi-step reaction with 4 steps

1.1: potassium tert-butylate / tetrahydrofuran / 1.83 h / 20 - 65 °C / Inert atmosphere

2.1: diethyl aluminiumcholoride / dichloromethane; hexane / 0.5 h / 0 °C / Inert atmosphere

2.2: 21.17 h / 0 - 20 °C

3.1: sodium hydride / N,N-dimethyl-formamide; paraffin oil / 0.42 h / 0 °C

3.2: 0.5 h / 0 - 20 °C

4.1: DavePhos; tris(dibenzylideneacetone)dipalladium⁽⁰⁾ chloroform complex / 1,4-dioxane / 0.17 h / Inert atmosphere

4.2: 2 h / 100 °C

With tris(dibenzylideneacetone)dipalladium⁽⁰⁾ chloroform complex; diethyl aluminiumcholoride; potassium tert-butylate; sodium hydride; DavePhos; In tetrahydrofuran; 1,4-dioxane; hexane; dichloromethane; N,N-dimethyl-formamide; paraffin oil;