2-{2-[(2-tert-butyl-phenylaminooxalyl)-amino]-propionylamino}-succinic acid 4-tert-butyl ester

Base Information

Chemical Name:2-{2-[(2-tert-butyl-phenylaminooxalyl)-amino]-propionylamino}-succinic acid 4-tert-butyl ester
CAS No.:868565-78-0
Molecular Formula:C₂₃H₃₃N₃O₇
Molecular Weight:463.531
Hs Code.:

2-{2-[(2-<i>tert</i>-butyl-phenylaminooxalyl)-amino]-propionylamino}-succinic acid 4-<i>tert</i>-butyl ester

Synonyms:2-{2-[(2-tert-butyl-phenylaminooxalyl)-amino]-propionylamino}-succinic acid 4-tert-butyl ester

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Chemical Property of 2-{2-[(2-tert-butyl-phenylaminooxalyl)-amino]-propionylamino}-succinic acid 4-tert-butyl ester

Chemical Property:

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Technology Process of 2-{2-[(2-tert-butyl-phenylaminooxalyl)-amino]-propionylamino}-succinic acid 4-tert-butyl ester

There total 4 articles about 2-{2-[(2-tert-butyl-phenylaminooxalyl)-amino]-propionylamino}-succinic acid 4-tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 2-{2-[(2-tert-butyl-phenylaminooxalyl)-amino]-propionylamino}-succinic acid 4-tert-butyl ester 1-methyl ester

: 868565-78-0
2-{2-[(2-tert-butyl-phenylaminooxalyl)-amino]-propionylamino}-succinic acid 4-tert-butyl ester

Guidance literature:: With lithium hydroxide; In 1,4-dioxane; at 20 ℃; for 1h;
DOI:10.1021/jm050307e

Reference yield:

: 6310-21-0
2-(1,1-dimethylethyl)-benzenamine

: 868565-78-0
2-{2-[(2-tert-butyl-phenylaminooxalyl)-amino]-propionylamino}-succinic acid 4-tert-butyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 70 percent / Et₃N / CH₂Cl₂ / 1 h / 0 - 20 °C

2: 58 percent / aq. LiOH / dioxane / 1 h / 20 °C

3: HATU; DIEA; N-methylmorpholine / CH₂Cl₂ / 2 h / 20 °C

4: aq. LiOH / dioxane / 1 h / 20 °C

With 4-methyl-morpholine; lithium hydroxide; triethylamine; N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In 1,4-dioxane; dichloromethane;
DOI:10.1021/jm050307e

Reference yield:

: 483334-60-7
methyl 2-[N-(2-tert-butylphenylamino)]-2-oxoacetate

: 868565-78-0
2-{2-[(2-tert-butyl-phenylaminooxalyl)-amino]-propionylamino}-succinic acid 4-tert-butyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 58 percent / aq. LiOH / dioxane / 1 h / 20 °C

2: HATU; DIEA; N-methylmorpholine / CH₂Cl₂ / 2 h / 20 °C

3: aq. LiOH / dioxane / 1 h / 20 °C

With 4-methyl-morpholine; lithium hydroxide; N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In 1,4-dioxane; dichloromethane;
DOI:10.1021/jm050307e