N-[4-cyano-2-(2,4-difluorophenoxy)phenyl]methanesulfonamide

Base Information

Chemical Name:N-[4-cyano-2-(2,4-difluorophenoxy)phenyl]methanesulfonamide
CAS No.:116686-16-9
Molecular Formula:C₁₄H₁₀F₂N₂O₃S
Molecular Weight:324.308
Hs Code.:
DSSTox Substance ID:DTXSID501190281
Nikkaji Number:J494.253A

Synonyms:SCHEMBL9655254;NPUFTSHCCYEUKN-UHFFFAOYSA-N;DTXSID501190281;N-[4-cyano-2-(2,4-difluorophenoxy)phenyl]methanesulfonamide;FK-867;4'-cyano-2'-(2,4-difluorophenoxy)methanesulfonanilide;116686-16-9

Suppliers and Price of N-[4-cyano-2-(2,4-difluorophenoxy)phenyl]methanesulfonamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-[4-cyano-2-(2,4-difluorophenoxy)phenyl]methanesulfonamide

Chemical Property:

XLogP3:2.7
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:7
Rotatable Bond Count:4
Exact Mass:324.03801968
Heavy Atom Count:22
Complexity:528

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CS(=O)(=O)NC1=C(C=C(C=C1)C#N)OC2=C(C=C(C=C2)F)F

Technology Process of N-[4-cyano-2-(2,4-difluorophenoxy)phenyl]methanesulfonamide

There total 5 articles about N-[4-cyano-2-(2,4-difluorophenoxy)phenyl]methanesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 21803-75-8
4-amino-3-chlorobenzonitrile

: 116686-16-9
4'-cyano-2'-(2,4-difluorophenoxy)methanesulfonanilide

Guidance literature:: Multi-step reaction with 4 steps

1: 1.) sodium nitrite, aq. HCl, 2.) sodium nitrite, cuprous oxide / 1.) from -5 deg C to 0 deg C, 10 min, 2.) H₂O, from -5 deg C to RT, 60 min

2: 78 percent / potassium carbonate / xylene / 5.5 h / Heating

3: iron, ammonium chloride, H₂O / ethanol / 0.5 h / Heating

4: pyridine / 0 °C

With pyridine; copper(I) oxide; hydrogenchloride; ammonium chloride; water; iron; potassium carbonate; sodium nitrite; In ethanol; xylene;
DOI:10.1248/cpb.40.2399

Reference yield:

: 34662-29-8
1-chloro-5-cyano-2-nitrobenzene

: 116686-16-9
4'-cyano-2'-(2,4-difluorophenoxy)methanesulfonanilide

Guidance literature:: Multi-step reaction with 3 steps

1: 78 percent / potassium carbonate / xylene / 5.5 h / Heating

2: iron, ammonium chloride, H₂O / ethanol / 0.5 h / Heating

3: pyridine / 0 °C

With pyridine; ammonium chloride; water; iron; potassium carbonate; In ethanol; xylene;
DOI:10.1248/cpb.40.2399

Reference yield:

: 116686-91-0
3-(2,4-difluorophenoxy)-4-nitrobenzonitrile

: 116686-16-9
4'-cyano-2'-(2,4-difluorophenoxy)methanesulfonanilide

Guidance literature:: Multi-step reaction with 2 steps

1: iron, ammonium chloride, H₂O / ethanol / 0.5 h / Heating

2: pyridine / 0 °C

With pyridine; ammonium chloride; water; iron; In ethanol;
DOI:10.1248/cpb.40.2399