2,2-Dimethyl-propionic acid (2R,3S)-4-{(S)-6-((S)-2,2-dimethyl-[1,3]dioxolan-4-yl)-6-formyl-2-[3-(4-methoxy-benzyloxy)-propyl]-5,6-dihydro-4H-pyran-3-yl}-2,3-dimethyl-butyl ester

Base Information

Chemical Name:2,2-Dimethyl-propionic acid (2R,3S)-4-{(S)-6-((S)-2,2-dimethyl-[1,3]dioxolan-4-yl)-6-formyl-2-[3-(4-methoxy-benzyloxy)-propyl]-5,6-dihydro-4H-pyran-3-yl}-2,3-dimethyl-butyl ester
CAS No.:851370-36-0
Molecular Formula:C₃₃H₅₀O₈
Molecular Weight:574.755
Hs Code.:

2,2-Dimethyl-propionic acid (2R,3S)-4-{(S)-6-((S)-2,2-dimethyl-[1,3]dioxolan-4-yl)-6-formyl-2-[3-(4-methoxy-benzyloxy)-propyl]-5,6-dihydro-4H-pyran-3-yl}-2,3-dimethyl-butyl ester

Synonyms:2,2-Dimethyl-propionic acid (2R,3S)-4-{(S)-6-((S)-2,2-dimethyl-[1,3]dioxolan-4-yl)-6-formyl-2-[3-(4-methoxy-benzyloxy)-propyl]-5,6-dihydro-4H-pyran-3-yl}-2,3-dimethyl-butyl ester

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 2,2-Dimethyl-propionic acid (2R,3S)-4-{(S)-6-((S)-2,2-dimethyl-[1,3]dioxolan-4-yl)-6-formyl-2-[3-(4-methoxy-benzyloxy)-propyl]-5,6-dihydro-4H-pyran-3-yl}-2,3-dimethyl-butyl ester

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of 2,2-Dimethyl-propionic acid (2R,3S)-4-{(S)-6-((S)-2,2-dimethyl-[1,3]dioxolan-4-yl)-6-formyl-2-[3-(4-methoxy-benzyloxy)-propyl]-5,6-dihydro-4H-pyran-3-yl}-2,3-dimethyl-butyl ester

There total 11 articles about 2,2-Dimethyl-propionic acid (2R,3S)-4-{(S)-6-((S)-2,2-dimethyl-[1,3]dioxolan-4-yl)-6-formyl-2-[3-(4-methoxy-benzyloxy)-propyl]-5,6-dihydro-4H-pyran-3-yl}-2,3-dimethyl-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 851370-26-8
2,2-Dimethyl-propionic acid (2R,3S)-4-{(R)-6-((S)-2,2-dimethyl-[1,3]dioxolan-4-yl)-6-hydroxymethyl-2-[3-(4-methoxy-benzyloxy)-propyl]-5,6-dihydro-4H-pyran-3-yl}-2,3-dimethyl-butyl ester

: 851370-36-0
2,2-Dimethyl-propionic acid (2R,3S)-4-{(S)-6-((S)-2,2-dimethyl-[1,3]dioxolan-4-yl)-6-formyl-2-[3-(4-methoxy-benzyloxy)-propyl]-5,6-dihydro-4H-pyran-3-yl}-2,3-dimethyl-butyl ester

Guidance literature:: With pyridine-SO₃ complex; dimethyl sulfoxide; triethylamine; In dichloromethane; at 20 ℃; for 12h;
DOI:10.1021/ol050321l

Reference yield:

: 851370-34-8
2,2-Dimethyl-propionic acid (2R,3R)-4-hydroxy-2,3-dimethyl-butyl ester

: 851370-36-0
2,2-Dimethyl-propionic acid (2R,3S)-4-{(S)-6-((S)-2,2-dimethyl-[1,3]dioxolan-4-yl)-6-formyl-2-[3-(4-methoxy-benzyloxy)-propyl]-5,6-dihydro-4H-pyran-3-yl}-2,3-dimethyl-butyl ester

Guidance literature:: Multi-step reaction with 6 steps

1.1: 95 percent / I₂; Ph₃P; imidazole / CH₂Cl₂ / 14 h / 20 °C

2.1: LDA / tetrahydrofuran / 0.33 h / -78 °C

2.2: 85 percent / DMPU / tetrahydrofuran / 3 h / 0 °C

3.1: 95 percent / KHMDS / tetrahydrofuran / -78 °C

4.1: t-BuLi / tetrahydrofuran; pentane / 0.17 h / -78 °C

4.2: ZnCl₂ / tetrahydrofuran; pentane / 0.08 h

4.3: 75 percent / NMP / Pd[P(t-Bu)3]2 / tetrahydrofuran; pentane / 0.5 h / -78 - 20 °C

5.1: 91 percent / tetra-n-butylammonium fluoride / tetrahydrofuran / 0.5 h / 20 °C

6.1: SO₃*pyridine; DMSO; Et₃N / CH₂Cl₂ / 12 h / 20 °C

With 1H-imidazole; pyridine-SO₃ complex; tetrabutyl ammonium fluoride; iodine; tert.-butyl lithium; potassium hexamethylsilazane; dimethyl sulfoxide; triethylamine; triphenylphosphine; lithium diisopropyl amide; In tetrahydrofuran; dichloromethane; pentane; 4.3: Negishi coupling;
DOI:10.1021/ol050321l

Reference yield:

: 851370-21-3
2,2-Dimethyl-propionic acid (2R,3R)-4-iodo-2,3-dimethyl-butyl ester

: 851370-36-0
2,2-Dimethyl-propionic acid (2R,3S)-4-{(S)-6-((S)-2,2-dimethyl-[1,3]dioxolan-4-yl)-6-formyl-2-[3-(4-methoxy-benzyloxy)-propyl]-5,6-dihydro-4H-pyran-3-yl}-2,3-dimethyl-butyl ester

Guidance literature:: Multi-step reaction with 5 steps

1.1: LDA / tetrahydrofuran / 0.33 h / -78 °C

1.2: 85 percent / DMPU / tetrahydrofuran / 3 h / 0 °C

2.1: 95 percent / KHMDS / tetrahydrofuran / -78 °C

3.1: t-BuLi / tetrahydrofuran; pentane / 0.17 h / -78 °C

3.2: ZnCl₂ / tetrahydrofuran; pentane / 0.08 h

3.3: 75 percent / NMP / Pd[P(t-Bu)3]2 / tetrahydrofuran; pentane / 0.5 h / -78 - 20 °C

4.1: 91 percent / tetra-n-butylammonium fluoride / tetrahydrofuran / 0.5 h / 20 °C

5.1: SO₃*pyridine; DMSO; Et₃N / CH₂Cl₂ / 12 h / 20 °C

With pyridine-SO₃ complex; tetrabutyl ammonium fluoride; tert.-butyl lithium; potassium hexamethylsilazane; dimethyl sulfoxide; triethylamine; lithium diisopropyl amide; In tetrahydrofuran; dichloromethane; pentane; 3.3: Negishi coupling;
DOI:10.1021/ol050321l