acetic acid 2-(4-acetylamino-2-chloro-phenylcarbamoyl)-4-chlorophenyl ester

Base Information

• Chemical Name: acetic acid 2-(4-acetylamino-2-chloro-phenylcarbamoyl)-4-chlorophenyl ester
• CAS No.: 1620390-51-3
• Molecular Formula: C₁₇H₁₄Cl₂N₂O₄
• Molecular Weight: 381.215

Synonyms:acetic acid 2-(4-acetylamino-2-chloro-phenylcarbamoyl)-4-chlorophenyl ester

Chemical Property of acetic acid 2-(4-acetylamino-2-chloro-phenylcarbamoyl)-4-chlorophenyl ester

Chemical Property:

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Technology Process of acetic acid 2-(4-acetylamino-2-chloro-phenylcarbamoyl)-4-chlorophenyl ester

There total 2 articles about acetic acid 2-(4-acetylamino-2-chloro-phenylcarbamoyl)-4-chlorophenyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

acetyl chloride (75-36-5) + N-(4-amino-2-chloro-phenyl)-5-chloro-2-hydroxy-benzamide (10558-45-9) → acetic acid 2-(4-acetylamino-2-chloro-phenylcarbamoyl)-4-chlorophenyl ester (1620390-51-3)

Guidance literature:

With triethylamine; In acetone; at 0 - 50 ℃; for 2h;

Reference yield:

Niclosamide (50-65-7) → acetic acid 2-(4-acetylamino-2-chloro-phenylcarbamoyl)-4-chlorophenyl ester (1620390-51-3)

Guidance literature:

Multi-step reaction with 2 steps

1: ammonium chloride; zinc / water; methanol / 16 h / 0 - 20 °C / Inert atmosphere

2: triethylamine / acetone / 2 h / 0 - 50 °C / Inert atmosphere

With ammonium chloride; triethylamine; zinc; In methanol; water; acetone;

DOI:10.1021/acs.jmedchem.0c01226

Reference yield: 97.0%

acetic acid 2-(4-acetylamino-2-chloro-phenylcarbamoyl)-4-chlorophenyl ester (1620390-51-3) → N-( 4-acetylamino-2-chlorophenyl)-5-chloro-2-hydroxybenzamide (1428328-99-7)

Guidance literature:

With lithium hydroxide; In methanol; water; at 0 - 20 ℃; for 1h;

upstream raw materials:

acetyl chloride

N-(4-amino-2-chloro-phenyl)-5-chloro-2-hydroxy-benzamide

Niclosamide

Downstream raw materials:

N-( 4-acetylamino-2-chlorophenyl)-5-chloro-2-hydroxybenzamide

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