N-((5-bromoquinolin-8-yl)methyl)-4-(trifluoromethyl)benzenesulfonamide

Base Information

Chemical Name:N-((5-bromoquinolin-8-yl)methyl)-4-(trifluoromethyl)benzenesulfonamide
CAS No.:1609646-70-9
Molecular Formula:C₁₇H₁₂BrF₃N₂O₂S
Molecular Weight:445.26
Hs Code.:

Synonyms:N-((5-bromoquinolin-8-yl)methyl)-4-(trifluoromethyl)benzenesulfonamide

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Chemical Property of N-((5-bromoquinolin-8-yl)methyl)-4-(trifluoromethyl)benzenesulfonamide

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Technology Process of N-((5-bromoquinolin-8-yl)methyl)-4-(trifluoromethyl)benzenesulfonamide

There total 3 articles about N-((5-bromoquinolin-8-yl)methyl)-4-(trifluoromethyl)benzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: 74316-55-5
5-bromo-8-methyl-quinoline

: 1152979-96-8
4-(trifluoromethyl)benzenesulfonyl azide

: 1609646-70-9
N-((5-bromoquinolin-8-yl)methyl)-4-(trifluoromethyl)benzenesulfonamide

Guidance literature:: With silver hexafluoroantimonate; [ruthenium(II)(η⁶-1-methyl-4-isopropyl-benzene)(chloride)(μ-chloride)]₂; zinc(II) acetate dihydrate; at 80 ℃; for 12h; Schlenk technique; Inert atmosphere;
DOI:10.1039/c5cc06230f

Reference yield:

: 39478-78-9
5-bromo-2-methylaniline

: 1609646-70-9
N-((5-bromoquinolin-8-yl)methyl)-4-(trifluoromethyl)benzenesulfonamide

Guidance literature:: Multi-step reaction with 2 steps

1: sodium iodide; sulfuric acid / water / 4 h / 140 - 145 °C / Inert atmosphere; Schlenk technique

2: dichloro(pentamethylcyclopentadienyl)rhodium (III) dimer; silver hexafluoroantimonate / dichloromethane / 12 h / 100 °C / Inert atmosphere; Schlenk technique

With silver hexafluoroantimonate; dichloro(pentamethylcyclopentadienyl)rhodium (III) dimer; sulfuric acid; sodium iodide; In dichloromethane; water;
DOI:10.1021/jo5008515

Reference yield:

: 2991-42-6
4-trifluorophenylsulfonyl chloride

: 1609646-70-9
N-((5-bromoquinolin-8-yl)methyl)-4-(trifluoromethyl)benzenesulfonamide

Guidance literature:: Multi-step reaction with 2 steps

1: sodium azide / water / 12 h / 0 - 20 °C / Inert atmosphere; Schlenk technique

2: dichloro(pentamethylcyclopentadienyl)rhodium (III) dimer; silver hexafluoroantimonate / dichloromethane / 12 h / 100 °C / Inert atmosphere; Schlenk technique

With silver hexafluoroantimonate; sodium azide; dichloro(pentamethylcyclopentadienyl)rhodium (III) dimer; In dichloromethane; water;
DOI:10.1021/jo5008515