74316-55-5

Basic information

• Product Name: 5-BROMO-8-METHYL-QUINOLINE
• Synonyms: 5-BROMO-8-METHYL-QUINOLINE
• CAS NO: 74316-55-5
• Molecular Formula: C₁₀H₈BrN
• Molecular Weight: 222.08
• Mol File: 74316-55-5.mol
• Article Data: 22

Chemical Properties

• Melting Point: 37-38 °C
• Boiling Point: 315.7±22.0 °C(Predicted)
• Appearance: /
• Density: 1.488±0.06 g/cm3(Predicted)
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 3.95±0.29(Predicted)
• CAS DataBase Reference: 5-BROMO-8-METHYL-QUINOLINE(CAS DataBase Reference)
• NIST Chemistry Reference: 5-BROMO-8-METHYL-QUINOLINE(74316-55-5)
• EPA Substance Registry System: 5-BROMO-8-METHYL-QUINOLINE(74316-55-5)

Safety Data

• Hazardous Substances Data: 74316-55-5(Hazardous Substances Data)

Usage

General Description

5-Bromo-8-methyl-quinoline is a chemical compound with the molecular formula C10H8BrN. It is a heterocyclic compound with a quinoline core structure and a bromine atom at the 5th position and a methyl group at the 8th position. This chemical is commonly used in the synthesis of pharmaceuticals, agrochemicals, and other organic compounds. It is known for its potential as a building block in the development of new drugs and bioactive molecules. Additionally, 5-Bromo-8-methyl-quinoline is also used in research and development activities in the field of medicinal chemistry and chemical biology. Its unique structure and reactivity make it a valuable tool for scientists and researchers in the study and development of new compounds with potential biological activities.

Upstream product

• 39478-78-9 5-bromo-2-methylaniline 
• 56-81-5 glycerol 
• 3054-95-3 acrylaldehyde diethyl acetal 
• 7726-95-6 bromine 
• 611-32-5 8-methylquinoline 

Downstream Products

• 74316-57-7 8-methylquinoline-5-carbonitrile 
• 1609646-70-9 N-((5-bromoquinolin-8-yl)methyl)-4-(trifluoromethyl)benzenesulfonamide 
• 1197331-55-7 5-(2,6-dichloro-3,5-dimethoxy-phenyl)-quinoline-8-carboxylic acid [4-(4-ethyl-piperazin-1-yl)-phenyl]-amide 
• 1197333-38-2 5-(2,6-difluoro-3,5-dimethoxy-phenyl)-quinoline-8-carboxylic acid ethyl ester 
• 1197333-41-7 5-(2-chloro-6-fluoro-3,5-dimethoxy-phenyl)-quinoline-8-carboxylic acid ethyl ester 
• 1197333-35-9 5-(2,6-dichloro-3,5-dimethoxy-phenyl)-quinoline-8-carboxylic acid 
• 1197333-40-6 5-(2-chloro-6-fluoro-3,5-dimethoxy-phenyl)-quinoline-8-carboxylic acid 
• 1197333-42-8 5-(2-fluoro-3,5-dimethoxy-phenyl)-quinoline-8-carboxylic acid ethyl ester 

Relevant articles and documents

1H-PYRAZOLO[4,3-d]PYRIMIDINE COMPOUNDS AS TOLL-LIKE RECEPTOR 7 (TLR7) AGONISTS

Compounds according to formula I are useful as agonists of Toll-like receptor 7 (TLR7). Such compounds can be used in cancer treatment, especially in combination with an anti-cancer immunotherapy agent, or as a vaccine adjuvant.

RhIII-Catalyzed Direct Heteroarylation of C(sp3)-H and C(sp2)-H Bonds in Heterocycles with N-Heteroaromatic Boronates

Herein, we disclose a RhIII-catalyzed heteroarylation of C(sp3)-H and C(sp2)-H bonds in heterocycles with organoboron reagents. This protocol displays high efficiency and excellent functional group tolerance. A range of heterocyclic boronates with strong coordinating atoms, including pyridine, pyrimidine, pyrazole, thiophene, and furan derivatives, can be extensively served as the coupling reagents. The direct heteroarylation method could supply potential application in terms of the synthesis of drug molecules with multiple heterocycles.

Corrigendum: Organo-Photoredox Catalyzed Oxidative Dehydrogenation of N-Heterocycles (Chemistry - A European Journal, (2017), 23, 57, (14167-14172), 10.1002/chem.201703642)

The authors have been alerted to an error that was unfortunately missed at the time of publication. Table was duplicated with Table 4. The correct version of Table 2 is shown below. The authors apologise for any inconvenience caused. Organo-photoredox catalyzed oxidative dehydrogenation of tetrahydroquinolines (THQ).[a,b] (Table presented.) [a] Reaction conditions: 1 (0.5 mmol), rose bengal (1.0 mol %), N,N-dimethylacetamide (2.0 mL), open air atmosphere under visible-light irradiation at room temperature for 24 h. [b] Isolated yields. [c] 0.1 mol % of photoredox catalyst for 28 h.