(1R,2R,5S,7R)-7-(5-(benzyloxy)pentyl)-5-pentyl-6,8-dioxabicyclo[3.2.1]octan-2-ol

Base Information

Chemical Name:(1R,2R,5S,7R)-7-(5-(benzyloxy)pentyl)-5-pentyl-6,8-dioxabicyclo[3.2.1]octan-2-ol
CAS No.:1422039-55-1
Molecular Formula:C₂₃H₃₆O₄
Molecular Weight:376.536
Hs Code.:

Synonyms:(1R,2R,5S,7R)-7-(5-(benzyloxy)pentyl)-5-pentyl-6,8-dioxabicyclo[3.2.1]octan-2-ol

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Chemical Property of (1R,2R,5S,7R)-7-(5-(benzyloxy)pentyl)-5-pentyl-6,8-dioxabicyclo[3.2.1]octan-2-ol

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Technology Process of (1R,2R,5S,7R)-7-(5-(benzyloxy)pentyl)-5-pentyl-6,8-dioxabicyclo[3.2.1]octan-2-ol

There total 8 articles about (1R,2R,5S,7R)-7-(5-(benzyloxy)pentyl)-5-pentyl-6,8-dioxabicyclo[3.2.1]octan-2-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

: 1422039-51-7
(6R,7S,8R)-1-(benzyloxy)tetradec-10-yne-6,7,8-triol

: 1422039-55-1
(1R,2R,5S,7R)-7-(5-(benzyloxy)pentyl)-5-pentyl-6,8-dioxabicyclo[3.2.1]octan-2-ol

Guidance literature:: With dichloro bis(acetonitrile) palladium(II); In acetonitrile; at 20 ℃; regioselective reaction; Inert atmosphere;
DOI:10.1016/j.tet.2012.12.045

Reference yield: 65.0%

: 1422039-47-1
(R)-1-((4R,5R)-5-(5-(benzyloxy)pentyl)-2,2-dimethyl-1,3-dioxolan-4-yl)non-3-yn-1-ol

: 1422039-55-1
(1R,2R,5S,7R)-7-(5-(benzyloxy)pentyl)-5-pentyl-6,8-dioxabicyclo[3.2.1]octan-2-ol

Guidance literature:: With dichloro bis(acetonitrile) palladium(II); In acetonitrile; at 20 ℃; regioselective reaction; Inert atmosphere;
DOI:10.1016/j.tet.2012.12.045

Reference yield:

: 13039-93-5
2,2:4,5-di-O-isopropylidene-D-arabinose

: 1422039-55-1
(1R,2R,5S,7R)-7-(5-(benzyloxy)pentyl)-5-pentyl-6,8-dioxabicyclo[3.2.1]octan-2-ol

Guidance literature:: Multi-step reaction with 7 steps

1.1: potassium tert-butylate / tetrahydrofuran / 0 °C

1.2: 0.5 h / 0 °C

2.1: hydrogen / ethanol / 0.5 h / 1034.32 Torr

3.1: toluene-4-sulfonic acid / methanol / 20 h / 0 °C

4.1: di(n-butyl)tin oxide; dmap; triethylamine / dichloromethane / 0.5 h / 20 °C / Cooling with ice

4.2: 4 h / 0 - 20 °C

5.1: potassium carbonate / methanol / 1 h / 0 °C / Inert atmosphere

6.1: n-butyllithium; boron trifluoride diethyl etherate / tetrahydrofuran / 0.75 h / -78 °C

7.1: dichloro bis(acetonitrile) palladium(II) / acetonitrile / 20 °C / Inert atmosphere

With dmap; dichloro bis(acetonitrile) palladium(II); n-butyllithium; boron trifluoride diethyl etherate; potassium tert-butylate; hydrogen; di(n-butyl)tin oxide; potassium carbonate; toluene-4-sulfonic acid; triethylamine; In tetrahydrofuran; methanol; ethanol; dichloromethane; acetonitrile; 1.1: |Wittig Olefination / 1.2: |Wittig Olefination;
DOI:10.1016/j.tet.2012.12.045