(4S)-2,2-Dimethyl-5β-[(4R)-2,2-dimethyl-1,3-dioxolane-4β-yl]-1,3-dioxolane-4α-carbaldehyde

Base Information

• Chemical Name: (4S)-2,2-Dimethyl-5β-[(4R)-2,2-dimethyl-1,3-dioxolane-4β-yl]-1,3-dioxolane-4α-carbaldehyde
• CAS No.: 13039-93-5
• Molecular Formula: C₁₁H₁₈O₅
• Molecular Weight: 230.261
• Hs Code.: 2940000080
• Mol file: 13039-93-5.mol

Synonyms:2,2:4,5-di-O-isopropylidene-D-arabinose

Chemical Property of (4S)-2,2-Dimethyl-5β-[(4R)-2,2-dimethyl-1,3-dioxolane-4β-yl]-1,3-dioxolane-4α-carbaldehyde

Chemical Property:

• Density: 1.1168 g/mL
• Storage Temp.: 2-8°C

Purity/Quality:

98% ^*data from raw suppliers

2,3:4,5-Di-O-isopropylidene-D-arabinose ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (4S)-2,2-Dimethyl-5β-[(4R)-2,2-dimethyl-1,3-dioxolane-4β-yl]-1,3-dioxolane-4α-carbaldehyde

There total 30 articles about (4S)-2,2-Dimethyl-5β-[(4R)-2,2-dimethyl-1,3-dioxolane-4β-yl]-1,3-dioxolane-4α-carbaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

(S)-1-((4R,4'R,5R)-2,2,2',2'-tetramethyl-4,4'-bi(1,3-dioxolan)-5-yl)ethane-1,2-diol (38145-93-6,58846-25-6,73745-56-9) → 2,2:4,5-di-O-isopropylidene-D-arabinose (13039-93-5)

Guidance literature:

With sodium periodate; sodium hydrogencarbonate; In dichloromethane; water; for 5h;

DOI:10.1055/s-2008-1072511

Reference yield: 90.0%

2,3:4,5-di-O-isopropylidene-D-arabinose diethyldithioacetal (50629-31-7) → 2,2:4,5-di-O-isopropylidene-D-arabinose (13039-93-5)

Guidance literature:

With mercury dichloride; mercury(II) oxide; In water; acetonitrile; at 20 ℃; for 1h;

DOI:10.1016/j.tet.2007.03.144

Reference yield: 85.0%

1,2:3,4-di-O-isopropylidene-D-mannitol (38145-93-6) → 2,2:4,5-di-O-isopropylidene-D-arabinose (13039-93-5)

Guidance literature:

With sodium periodate; sodium hydrogencarbonate; In ethanol; for 4h; Ambient temperature;

DOI:10.1021/jo00090a014

upstream raw materials:

1,2:3,4-di-O-isopropylidene-D-mannitol

(S)-1-((4R,4'R,5R)-2,2,2',2'-tetramethyl-4,4'-bi(1,3-dioxolan)-5-yl)ethane-1,2-diol

2,3:4,5-di-O-isopropylidene-D-arabinose diethyldithioacetal

2,3:4,5-di-O-isopropylidene-aldehydo-D-ribose

Downstream raw materials:

(1S)-1-cyclohexyl-O²,O³;O⁴,O⁵-diisopropyliden-D-arabitol

(R)-phenyl((4R,4'R,5R)-2,2,2',2'-tetramethyl-4,4'-bi(1,3-dioxolan)-5-yl)methanol

(S)-phenyl((4R,4'R,5R)-2,2,2',2'-tetramethyl-4,4'-bi(1,3-dioxolan)-5-yl)methanol

L-(+)-arabinose dibenzyl thioacetal