tert-butyl 4-(3-{3-[3-(3,5-difluorophenyl)-6-oxo-6H-pyridazin-1-ylmethyl]benzoylamino}-2-oxopropyl)piperidine-1-carboxylate

Base Information

Chemical Name:tert-butyl 4-(3-{3-[3-(3,5-difluorophenyl)-6-oxo-6H-pyridazin-1-ylmethyl]benzoylamino}-2-oxopropyl)piperidine-1-carboxylate
CAS No.:1119204-97-5
Molecular Formula:C₃₁H₃₄F₂N₄O₅
Molecular Weight:580.632
Hs Code.:

Synonyms:tert-butyl 4-(3-{3-[3-(3,5-difluorophenyl)-6-oxo-6H-pyridazin-1-ylmethyl]benzoylamino}-2-oxopropyl)piperidine-1-carboxylate

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Chemical Property of tert-butyl 4-(3-{3-[3-(3,5-difluorophenyl)-6-oxo-6H-pyridazin-1-ylmethyl]benzoylamino}-2-oxopropyl)piperidine-1-carboxylate

Chemical Property:

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Technology Process of tert-butyl 4-(3-{3-[3-(3,5-difluorophenyl)-6-oxo-6H-pyridazin-1-ylmethyl]benzoylamino}-2-oxopropyl)piperidine-1-carboxylate

There total 9 articles about tert-butyl 4-(3-{3-[3-(3,5-difluorophenyl)-6-oxo-6H-pyridazin-1-ylmethyl]benzoylamino}-2-oxopropyl)piperidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1119204-95-3
tert-butyl 4-(3-{3-[3-(3,5-difluorophenyl)-6-oxo-6H-pyridazin-1-ylmethyl]benzoylamino}-2-hydroxypropyl)piperidine-1-carboxylate

: 1119204-97-5
tert-butyl 4-(3-{3-[3-(3,5-difluorophenyl)-6-oxo-6H-pyridazin-1-ylmethyl]benzoylamino}-2-oxopropyl)piperidine-1-carboxylate

Guidance literature:: With Dess-Martin periodane; In dichloromethane; at 20 ℃; for 1h;

Reference yield:

: 156545-07-2
3,5-difluorophenylboronic acid

: 1119204-97-5
tert-butyl 4-(3-{3-[3-(3,5-difluorophenyl)-6-oxo-6H-pyridazin-1-ylmethyl]benzoylamino}-2-oxopropyl)piperidine-1-carboxylate

Guidance literature:: Multi-step reaction with 6 steps

1: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / ethanol; water / 5 h / 100 °C

2: water; formic acid / 18 h / Heating

3: caesium carbonate / N,N-dimethyl-formamide / 20 h / 20 °C

4: sodium hydroxide; water / methanol / 18 h / Reflux

5: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / N,N-dimethyl-formamide / 18 h / 20 °C

6: Dess-Martin periodane / dichloromethane / 1 h / 20 °C

With formic acid; water; sodium carbonate; benzotriazol-1-ol; caesium carbonate; Dess-Martin periodane; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; sodium hydroxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In methanol; ethanol; dichloromethane; water; N,N-dimethyl-formamide;

Reference yield:

: 1007099-00-4
3-[3-(3,5-difluorophenyl)-6-oxo-6H-pyridazin-1-ylmethyl]benzoic acid

: 1119204-97-5
tert-butyl 4-(3-{3-[3-(3,5-difluorophenyl)-6-oxo-6H-pyridazin-1-ylmethyl]benzoylamino}-2-oxopropyl)piperidine-1-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / N,N-dimethyl-formamide / 18 h / 20 °C

2: Dess-Martin periodane / dichloromethane / 1 h / 20 °C

With benzotriazol-1-ol; Dess-Martin periodane; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; N,N-dimethyl-formamide;