tert-butyl 4-(3-{3-[3-(3,5-difluorophenyl)-6-oxo-6H-pyridazin-1-ylmethyl]benzoylamino}-2-hydroxypropyl)piperidine-1-carboxylate

Base Information

Chemical Name:tert-butyl 4-(3-{3-[3-(3,5-difluorophenyl)-6-oxo-6H-pyridazin-1-ylmethyl]benzoylamino}-2-hydroxypropyl)piperidine-1-carboxylate
CAS No.:1119204-95-3
Molecular Formula:C₃₁H₃₆F₂N₄O₅
Molecular Weight:582.647
Hs Code.:

Synonyms:tert-butyl 4-(3-{3-[3-(3,5-difluorophenyl)-6-oxo-6H-pyridazin-1-ylmethyl]benzoylamino}-2-hydroxypropyl)piperidine-1-carboxylate

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Chemical Property of tert-butyl 4-(3-{3-[3-(3,5-difluorophenyl)-6-oxo-6H-pyridazin-1-ylmethyl]benzoylamino}-2-hydroxypropyl)piperidine-1-carboxylate

Chemical Property:

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Technology Process of tert-butyl 4-(3-{3-[3-(3,5-difluorophenyl)-6-oxo-6H-pyridazin-1-ylmethyl]benzoylamino}-2-hydroxypropyl)piperidine-1-carboxylate

There total 7 articles about tert-butyl 4-(3-{3-[3-(3,5-difluorophenyl)-6-oxo-6H-pyridazin-1-ylmethyl]benzoylamino}-2-hydroxypropyl)piperidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1007099-00-4
3-[3-(3,5-difluorophenyl)-6-oxo-6H-pyridazin-1-ylmethyl]benzoic acid

: 1119205-17-2
tert-butyl 4-(3-amino-2-hydroxypropyl)piperidine-1-carboxylate

: 1119204-95-3
tert-butyl 4-(3-{3-[3-(3,5-difluorophenyl)-6-oxo-6H-pyridazin-1-ylmethyl]benzoylamino}-2-hydroxypropyl)piperidine-1-carboxylate

Guidance literature:: With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In N,N-dimethyl-formamide; at 20 ℃; for 18h;

Reference yield:

: 156545-07-2
3,5-difluorophenylboronic acid

: 1119204-95-3
tert-butyl 4-(3-{3-[3-(3,5-difluorophenyl)-6-oxo-6H-pyridazin-1-ylmethyl]benzoylamino}-2-hydroxypropyl)piperidine-1-carboxylate

Guidance literature:: Multi-step reaction with 5 steps

1: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / ethanol; water / 5 h / 100 °C

2: water; formic acid / 18 h / Heating

3: caesium carbonate / N,N-dimethyl-formamide / 20 h / 20 °C

4: sodium hydroxide; water / methanol / 18 h / Reflux

5: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / N,N-dimethyl-formamide / 18 h / 20 °C

With formic acid; water; sodium carbonate; benzotriazol-1-ol; caesium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; sodium hydroxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In methanol; ethanol; water; N,N-dimethyl-formamide;

Reference yield:

: 123577-99-1
3′,5′-difluoroacetophenone

: 1119204-95-3
tert-butyl 4-(3-{3-[3-(3,5-difluorophenyl)-6-oxo-6H-pyridazin-1-ylmethyl]benzoylamino}-2-hydroxypropyl)piperidine-1-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1.1: acetic acid / 18 h / 95 °C

1.2: 4 h / 30 - 95 °C

2.1: caesium carbonate / N,N-dimethyl-formamide / 20 h / 20 °C

3.1: sodium hydroxide; water / methanol / 18 h / Reflux

4.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / N,N-dimethyl-formamide / 18 h / 20 °C

With water; benzotriazol-1-ol; caesium carbonate; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; sodium hydroxide; In methanol; N,N-dimethyl-formamide;