N-(2-chlorobenzoyl)glycine-2-(1,4-dihydro-1-methyl-2,4-dioxo-3(2H)-quinazolinyl)ethyl ester

Base Information

Chemical Name:N-(2-chlorobenzoyl)glycine-2-(1,4-dihydro-1-methyl-2,4-dioxo-3(2H)-quinazolinyl)ethyl ester
CAS No.:1400799-32-7
Molecular Formula:C₂₀H₁₈ClN₃O₅
Molecular Weight:415.833
Hs Code.:

Synonyms:N-(2-chlorobenzoyl)glycine-2-(1,4-dihydro-1-methyl-2,4-dioxo-3(2H)-quinazolinyl)ethyl ester

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Chemical Property of N-(2-chlorobenzoyl)glycine-2-(1,4-dihydro-1-methyl-2,4-dioxo-3(2H)-quinazolinyl)ethyl ester

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Technology Process of N-(2-chlorobenzoyl)glycine-2-(1,4-dihydro-1-methyl-2,4-dioxo-3(2H)-quinazolinyl)ethyl ester

There total 7 articles about N-(2-chlorobenzoyl)glycine-2-(1,4-dihydro-1-methyl-2,4-dioxo-3(2H)-quinazolinyl)ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 51.0%

: 1400799-43-0
glycine-2-(1,4-dihydro-1-methyl-2,4-dioxo-3(2H)-quinazolinyl)ethyl ester

: 609-65-4
o-chlorobenzoyl chloride

: 1400799-32-7
N-(2-chlorobenzoyl)glycine-2-(1,4-dihydro-1-methyl-2,4-dioxo-3(2H)-quinazolinyl)ethyl ester

Guidance literature:: With triethylamine; In dichloromethane; at 0 - 5 ℃; for 1h;
DOI:10.1007/s00044-013-0813-z

Reference yield:

: 85-91-6
Methyl N-methylanthranilate

: 1400799-32-7
N-(2-chlorobenzoyl)glycine-2-(1,4-dihydro-1-methyl-2,4-dioxo-3(2H)-quinazolinyl)ethyl ester

Guidance literature:: Multi-step reaction with 6 steps

1.1: sodium hydroxide / water; methanol / 1 h / 60 °C

2.1: 5 h / 150 °C

3.1: sodium hydroxide / N,N-dimethyl-formamide / 5 h / 80 °C

4.1: dicyclohexyl-carbodiimide; dmap / dichloromethane / 4 h / 0 - 20 °C

5.1: trifluoroacetic acid / dichloromethane / 0 - 20 °C

5.2: 5 h / 20 °C

6.1: triethylamine / dichloromethane / 1 h / 0 - 5 °C

With dmap; triethylamine; dicyclohexyl-carbodiimide; trifluoroacetic acid; sodium hydroxide; In methanol; dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1007/s00044-013-0813-z

Reference yield:

: 134-20-3
2-carbomethoxyaniline

: 1400799-32-7
N-(2-chlorobenzoyl)glycine-2-(1,4-dihydro-1-methyl-2,4-dioxo-3(2H)-quinazolinyl)ethyl ester

Guidance literature:: Multi-step reaction with 7 steps

1.1: sodium hydroxide / N,N-dimethyl-formamide / 0.17 h / 20 °C

1.2: 8 h / 20 - 50 °C

2.1: sodium hydroxide / water; methanol / 1 h / 60 °C

3.1: 5 h / 150 °C

4.1: sodium hydroxide / N,N-dimethyl-formamide / 5 h / 80 °C

5.1: dicyclohexyl-carbodiimide; dmap / dichloromethane / 4 h / 0 - 20 °C

6.1: trifluoroacetic acid / dichloromethane / 0 - 20 °C

6.2: 5 h / 20 °C

7.1: triethylamine / dichloromethane / 1 h / 0 - 5 °C

With dmap; triethylamine; dicyclohexyl-carbodiimide; trifluoroacetic acid; sodium hydroxide; In methanol; dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1007/s00044-013-0813-z