1-((2-(2-benzyloxyphenyl)-5-methoxybenzofuran-4-yl)methyl)-N,N-dimethylpiperidin-4-amine

Base Information

Chemical Name:1-((2-(2-benzyloxyphenyl)-5-methoxybenzofuran-4-yl)methyl)-N,N-dimethylpiperidin-4-amine
CAS No.:1448962-78-4
Molecular Formula:C₃₀H₃₄N₂O₃
Molecular Weight:470.612
Hs Code.:

Synonyms:1-((2-(2-benzyloxyphenyl)-5-methoxybenzofuran-4-yl)methyl)-N,N-dimethylpiperidin-4-amine

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Chemical Property of 1-((2-(2-benzyloxyphenyl)-5-methoxybenzofuran-4-yl)methyl)-N,N-dimethylpiperidin-4-amine

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Technology Process of 1-((2-(2-benzyloxyphenyl)-5-methoxybenzofuran-4-yl)methyl)-N,N-dimethylpiperidin-4-amine

There total 5 articles about 1-((2-(2-benzyloxyphenyl)-5-methoxybenzofuran-4-yl)methyl)-N,N-dimethylpiperidin-4-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 50533-97-6
dimethyl-piperidin-4-yl-amine

: 1448962-77-3
C₂₃H₁₈O₄

: 1448962-78-4
1-((2-(2-benzyloxyphenyl)-5-methoxybenzofuran-4-yl)methyl)-N,N-dimethylpiperidin-4-amine

Guidance literature:: With sodium cyanoborohydride; acetic acid; In methanol; at 20 ℃; for 5h;
DOI:10.1016/j.ejmech.2014.05.014

Reference yield:

: 1448962-74-0
2-(2-fluorophenyl)-5-hydroxybenzofuran-4-carbaldehyde

: 1448962-78-4
1-((2-(2-benzyloxyphenyl)-5-methoxybenzofuran-4-yl)methyl)-N,N-dimethylpiperidin-4-amine

Guidance literature:: Multi-step reaction with 3 steps

1.1: potassium carbonate / acetone / 16 h / Reflux

2.1: potassium tert-butylate / N,N-dimethyl-formamide / 0.17 h / 20 °C

2.2: 120 h / 80 °C

2.3: 16 h / 20 °C

3.1: sodium cyanoborohydride; acetic acid / methanol / 5 h / 20 °C

With potassium tert-butylate; sodium cyanoborohydride; potassium carbonate; acetic acid; In methanol; N,N-dimethyl-formamide; acetone;
DOI:10.1016/j.ejmech.2014.05.014

Reference yield:

: 241127-72-0
2-bromo-3,6-dihydroxy-benzaldehyde

: 1448962-78-4
1-((2-(2-benzyloxyphenyl)-5-methoxybenzofuran-4-yl)methyl)-N,N-dimethylpiperidin-4-amine

Guidance literature:: Multi-step reaction with 5 steps

1.1: triethylamine / tetrahydrofuran / 0.17 h / 20 °C / Inert atmosphere

2.1: bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; diisopropylamine; tri tert-butylphosphoniumtetrafluoroborate / 16 h / 60 °C

2.2: 2 h / Reflux

3.1: potassium carbonate / acetone / 16 h / Reflux

4.1: potassium tert-butylate / N,N-dimethyl-formamide / 0.17 h / 20 °C

4.2: 120 h / 80 °C

4.3: 16 h / 20 °C

5.1: sodium cyanoborohydride; acetic acid / methanol / 5 h / 20 °C

With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; potassium tert-butylate; sodium cyanoborohydride; potassium carbonate; acetic acid; triethylamine; diisopropylamine; tri tert-butylphosphoniumtetrafluoroborate; In tetrahydrofuran; methanol; N,N-dimethyl-formamide; acetone;
DOI:10.1016/j.ejmech.2014.05.014