241127-72-0Relevant academic research and scientific papers
Asymmetric Total Syntheses and Structure Revisions of Eurotiumide A and Eurotiumide B, and Their Evaluation as Natural Fluorescent Probes
Nakayama, Atsushi,Sato, Hideo,Karanjit, Sangita,Hayashi, Naoki,Oda, Masataka,Namba, Kosuke
, p. 4013 - 4017 (2018)
Asymmetric total syntheses and structure revisions of dihydroisocoumarin-type natural products, eurotiumide A and eurotiumide B have been described. The key features of these total syntheses are the asymmetric Shi epoxidation, regio- and stereoselective e
Total synthesis of (+)-clavilactone A and (-)-clavilactone B by ring-opening/ring-closing metathesis
Takao, Ken-Ichi,Nanamiya, Ryuki,Fukushima, Yuuki,Namba, Ayumi,Yoshida, Keisuke,Tadano, Kin-Ichi
, p. 5582 - 5585 (2013)
The enantioselective total synthesis of natural enantiomers of clavilactones A and B has been achieved. A key feature of the synthesis is the use of a ring-opening/ring-closing metathesis, which allows the one-pot transformation of a strained cyclobutenecarboxylate into a γ-butenolide.
Synthesis, cytotoxicity and pro-apoptosis activity of isoquinoline quinones
Ni, Hua,Xia, Chao,Zhao, Yu
, p. 2861 - 2869 (2017)
Mansouramycins are newly isolated cytotoxic isoquinoline quinones from marine organism. To find novel anticancer agents, eighteen isoquinoline quinones 7a–7r as Mansouramycins analogs were designed and synthesized. Most of these compounds displayed modera
Concise syntheses of violaceoids A and C
Narita, Koichi,Kimura, Ryuhei,Satoh, Hiroka,Watanabe, Kazuhiro,Yoshimura, Yuichi
, p. 232 - 235 (2021/02/06)
The concise syntheses of two alkylated hydroquinone natural products, violaceoids A and C, were accomplished by a protecting-group-free method employing the commercially available 2,5-dihydroxybenzal-dehyde as the starting material. The key strategy of the syntheses is the utilization of alkenylboronic acid as both the coupling and temporary protective reagents to efficiently introduce the requisite alkenyl side chain of violaceoid A. Moreover, the synthesis of violaceoid C is reported here for the first time.
Total synthesis of the aglycone of IB-00208
Knueppel, Daniel,Yang, Jingyue,Cheng, Bo,Mans, Douglas,Martin, Stephen F.
, p. 5741 - 5757 (2015/08/03)
Abstract A total synthesis of the aglycone of IB-00208 was accomplished in 22 steps using a newly developed approach towards polycyclic 1,4-dioxygenated xanthones from benzocyclobutenones. The generality of this entry to xanthones was initially established on several model systems before it was successfully applied to the construction of the hexacyclic core of the natural product. A new and potentially general approach towards angularly fused benzocyclobutenones using ring-closing metathesis (RCM) was also developed.
HCV PROTEASE INHIBITORS
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Paragraph 0092; 0093, (2014/06/24)
The present invention discloses a compound of general formula (I); A is O, S, CH, NH or NR', when O links with Z3, Z1 is N or CRZ1, Z2 is CRZ2, when Z1 links with O, Z2 is CH, Z3 is C-Ar; Ra, Rb, Rc and Rd independently is H, OH, halogen or -Y1-Rm; A1 is NH or CH2; R1' is alkyl, aryl, cycloalkyl, heterocycloalkyl or heteroaryl; A2 is N, O or linking bond; R1 is hydrogen, or, R1 linking covalently with R3 forms C5-C9 saturated or unsaturated hydrocarbon chain substituted by O or N; R3 is alkyl, cycloalkyl, heterocycloalkyl, alkyl substituted by cycloalky etc; R4 is alkoxy-CO, alkyl-NHCO, (alkyl)2NCO, or formyl substituted by aryl, cycloalkyl, heterocycloalkyl.
HCV Protease Inhibitors
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Paragraph 0198-0200, (2014/06/24)
A compound of general formula (I); A is O, S, CH, NH or NR′, when O links with Z3, Z1 is N or CRZ1, Z2 is CRZ2, when Z1 links with O, Z2 is CH, Z3 is C—Ar; Ra, Rb, Rc and Rd independently is H, OH, halogen or —Y1—Rm; A1 is NH or CH2; R1′ is alkyl, aryl, cycloalkyl, heterocycloalkyl or heteroaryl; A2 is N, O or linking bond; R1 is hydrogen, or, R1 linking covalently with R3 forms C5-C9 saturated or unsaturated hydrocarbon chain substituted by O or N; R3 is alkyl, cycloalkyl, heterocycloalkyl, alkyl substituted by cycloalkyl etc; R4 is alkoxy-CO, alkyl-NHCO, (alkyl)2NCO, or formyl substituted by aryl, cycloalkyl, heterocycloalkyl.
Total syntheses of graphisin A and sydowinin B
Little, Andrew,Porco, John A.
supporting information; experimental part, p. 2862 - 2865 (2012/07/17)
Efficient syntheses of the highly substituted benzophenone graphisin A and the xanthone sydowinin B are described. Key steps involve aryl anion addition to substituted benzaldehyde derivatives, subsequent methyl ester installation, and dehydrative cycliza
Synthetic studies toward (+)-cortistatin A
Wang, Zhang,Dai, Mingji,Park, Peter K.,Danishefsky, Samuel J.
scheme or table, p. 10249 - 10260 (2012/01/05)
We describe herein the synthesis of a late-stage intermediate en route to cortistatin A. Key transformations included a Snieckus-like cascade sequence culminating in a 6π-electrocyclization, an alkylative dearomatization, and the stereoselective functiona
Sporolide B: Synthetic studies
Gladding, Jeffery A.,Bacci, James P.,Shaw, Scott A.,Smith III, Amos B.
scheme or table, p. 6697 - 6706 (2011/10/01)
Studies directed toward the synthesis of the architecturally complex marine natural product sporolide B are described. Synthetic analysis suggested advanced hydroquinone and benzodiquinane fragments, which upon elaboration were successfully united via an
