4-(4-amino-2-fluorophenoxy)-N-(4-methoxybenzyl)pyrimidin-2-amine

Base Information

• Chemical Name: 4-(4-amino-2-fluorophenoxy)-N-(4-methoxybenzyl)pyrimidin-2-amine
• CAS No.: 868733-46-4
• Molecular Formula: C₁₈H₁₇FN₄O₂
• Molecular Weight: 340.357
• Mol file: 868733-46-4.mol

Synonyms:4-(4-amino-2-fluorophenoxy)-N-(4-methoxybenzyl)pyrimidin-2-amine

Chemical Property of 4-(4-amino-2-fluorophenoxy)-N-(4-methoxybenzyl)pyrimidin-2-amine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

Useful:

Technology Process of 4-(4-amino-2-fluorophenoxy)-N-(4-methoxybenzyl)pyrimidin-2-amine

There total 4 articles about 4-(4-amino-2-fluorophenoxy)-N-(4-methoxybenzyl)pyrimidin-2-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

4-(2-fluoro-4-nitrophenoxy)-N-(4-methoxybenzyl)pyrimidin-2-amine (868733-45-3) → 4-(4-amino-2-fluorophenoxy)-N-(4-methoxybenzyl)pyrimidin-2-amine (868733-46-4)

Guidance literature:

With ammonium chloride; zinc; In tetrahydrofuran; methanol; at 20 ℃; for 1h; Inert atmosphere;

DOI:10.1016/j.ejmech.2013.10.037

Reference yield: 95.0%

→ 4-(4-amino-2-fluorophenoxy)-N-(4-methoxybenzyl)pyrimidin-2-amine (868733-46-4)

Guidance literature:

Reference yield:

2-chloro-4-(2-fluoro-4-nitrophenoxy)pyrimidine (868733-43-1) → 4-(4-amino-2-fluorophenoxy)-N-(4-methoxybenzyl)pyrimidin-2-amine (868733-46-4)

Guidance literature:

Multi-step reaction with 2 steps

1: potassium carbonate / N,N-dimethyl-formamide / 0.5 h / 60 °C / Sealed tube; Inert atmosphere

2: zinc; ammonium chloride / methanol; tetrahydrofuran / 1 h / 20 °C / Inert atmosphere

With potassium carbonate; ammonium chloride; zinc; In tetrahydrofuran; methanol; N,N-dimethyl-formamide;

DOI:10.1016/j.ejmech.2013.10.037

upstream raw materials:

2-chloro-4-(2-fluoro-4-nitrophenoxy)pyrimidine

2-fluoro-4-nitrophenol

4-(2-fluoro-4-nitrophenoxy)-N-(4-methoxybenzyl)pyrimidin-2-amine

Downstream raw materials:

N-(3-fluoro-4-((2-((4-methoxybenzyl)amino)pyrimidin-4-yl)oxy)phenyl)-1-(4-fluorophenyl)-4-iodo-2-oxo-1,2-dihydropyridine-3-carboxamide