Cmpda

Base Information

• Chemical Name: Cmpda
• CAS No.: 380607-77-2
• Molecular Formula: C₁₆H₂₈N₂O₄S₂
• Molecular Weight: 376.541
• UNII: A36XX25K37
• Wikidata: Q27465085
• Mol file: 380607-77-2.mol

Synonyms:CMPDA;380607-77-2;N,N'-(1,4-Phenylenedi-2,1-ethanediyl)bis-2-propanesulfonamide;A36XX25K37;N-[2-[4-[2-(propan-2-ylsulfonylamino)ethyl]phenyl]ethyl]propane-2-sulfonamide;N,N'-(Benzene-1,4-Diyldiethane-2,1-Diyl)dipropane-2-Sulfonamide;2-Propanesulfonamide, N,N'-(1,4-phenylenedi-2,1-ethanediyl)bis-;UNII-A36XX25K37;SCHEMBL6565144;BCP23929;AKOS024458123;CS-3632;HY-12508;MS-26117;E99011;Q27465085;N,N'-(2,2'-(1,4-phenylene)bis(ethane-2,1-diyl))dipropane-2-sulfonamide;RNN

Chemical Property of Cmpda

Chemical Property:

• XLogP3: 2.2
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 6
• Rotatable Bond Count: 10
• Exact Mass: 376.14904973
• Heavy Atom Count: 24
• Complexity: 500

Purity/Quality:

>98% ^*data from raw suppliers

CMPDA ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: CC(C)S(=O)(=O)NCCC1=CC=C(C=C1)CCNS(=O)(=O)C(C)C
• Description: CMPDA is a positive allosteric modulator of the ionotropic glutamate receptor GluA2. It increases glutamate-induced calcium influx into HEK293 cells expressing human GluA2i or GluA2o receptors (EC50s = 45.4 and 63.4 nM, respectively). CMPDA (10 μM) inhibits desensitization of rat GluA2o and GluA2i receptors, as well as slows the rate of deactivation of GluA2o, but not GluA2i, receptors, in HEK293 cells.

Technology Process of Cmpda

There total 1 articles about Cmpda which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 11.0%

Isopropylsulfonyl chloride (10147-37-2) + 1,4-bis(2-aminoethyl)benzene (7423-50-9) → [(methylethyl)sulfonyl]{2-[4-(2-{[(methylethyl)sulfonyl]amino}ethyl)phenyl]ethyl}amine (380607-77-2)

Guidance literature:

Isopropylsulfonyl chloride; 1,4-bis(2-aminoethyl)benzene; With 1,8-diazabicyclo[5.4.0]undec-7-ene; In tetrahydrofuran; dichloromethane; at 0 - 20 ℃; for 0.5h;

With hydrogenchloride; pH=4 - 5;

upstream raw materials:

Isopropylsulfonyl chloride

1,4-bis(2-aminoethyl)benzene

Refernces