7423-50-9

Upstream product

• 622-75-3 1,4-phenylenediacetonitrile 

Downstream Products

• 15449-24-8 1,4-bis-(2-isocyanato-ethyl)-benzene 
• 3953-93-3 1,4-bis-(2-ureido-ethyl)-benzene 
• 58594-69-7 1,4-bis-(2-acetylamino-ethyl)-benzene 
• 61796-69-8 Undec-10-enoic acid {2-[4-(2-undec-10-enoylamino-ethyl)-phenyl]-ethyl}-amide 
• 380607-77-2 [(methylethyl)sulfonyl]{2-[4-(2-{[(methylethyl)sulfonyl]amino}ethyl)phenyl]ethyl}amine 
• 41640-58-8 C₂₈H₃₆N₂O₆ 
• 681465-92-9 1,3-bis-acetylamino-2,5-bis-(2-benzoylamino-ethyl)-benzene 
• 681465-88-3 2,5-bis-(2-benzoylamino-ethyl)-1,3-dinitro-benzene 
• 681465-86-1 1,4-bis-acetylamino-2,5-bis-(2-benzoylamino-ethyl)-benzene 
• 681465-83-8 acetic acid-[4-nitro-2,5-bis-(2-benzoylamino-ethyl)-anilide] 
• 681465-81-6 acetic acid-[2,5-bis-(2-benzoylamino-ethyl)-anilide] 
• 681465-77-0 1,4-bis-(2-benzoylamino-ethyl)-2-nitro-benzene 
• 681465-79-2 2,5-bis-(2-benzoylamino-ethyl)-aniline 

Relevant academic research and scientific papers

Design, synthesis, and solution behaviour of small polyamines as switchable water additives

The practice of adding salt to water to induce salting out of contaminants or to break emulsions and suspensions is generally avoided industrially because of the expense of the necessary treatment of the salty water afterwards. However, the use of switchable water, an aqueous solvent with switchable ionic strength, allows for reversible generation and elimination of salts in aqueous solution, through the introduction and removal of CO2. In the effort to improve the efficiency of these switchable salts, a physical study modeling their reactivity and solution behaviour has been performed, resulting in a set of design principles for future switchable water additives. The resulting polyamines synthesized using this template show the highest efficiency recorded for a switchable water additive. The Royal Society of Chemistry 2012.

Exploiting protein fluctuations at the active-site Gorge of human cholinesterases: Further optimization of the design strategy to develop extremely potent inhibitors

Protein conformational fluctuations are critical for biological functions, although the relationship between protein motion and function has yet to be fully explored. By a thorough bioinformatics analysis of cholinesterases (ChEs), we identified specific hot spots, responsible for protein fluctuations and functions, and those active-site residues that play a role in modulating the cooperative network among the key substructures. This drew the optimization of our design strategy to discover potent and reversible inhibitors of human acetylcholinesterase and butyrylcholinesterase (hAChE and hBuChE) that selectively interact with specific protein substructures. Accordingly, two tricyclic moieties differently spaced by functionalized linkers were investigated as molecular yardsticks to probe the finest interactions with specific hot spots in the hChE gorge. A number of SAR trends were identified, and the multisite inhibitors 3a and 3d were found to be the most potent inhibitors of hBuChE and hAChE known to date.

Structuring of bridged silsesquioxanes via cooperative weak interactions: H-bonding of urea groups and hydrophobic interactions of long alkylene chains

Lamellar-bridged silsesquioxanes were obtained by the acid-catalysed hydrolytic condensation of a series of bissilylated organobridged molecular precursors. It was found that exploiting cooperative effects between the molecular interactions created by lon

Sulfonamide derivatives

The present invention relates to a compound of formula (I) or a pharmaceutically acceptable salt thereof which is useful for the treatment of conditions associated with glutamate hypofunction, such as psychiatric and neurological disorders

Enzymatic formation of lactams in organic solvents

Porcine pancreatic lipase in organic solvents catalyses the intramolecular cyclisation of aminoesters and the formation of macrocyclic bislactams from diesters and diamines.