(4,4-bis-hydroperoxy-cyclohexyl)-acetic acid ethyl ester

Base Information

• Chemical Name: (4,4-bis-hydroperoxy-cyclohexyl)-acetic acid ethyl ester
• CAS No.: 923267-17-8
• Molecular Formula: C₁₀H₁₈O₆
• Molecular Weight: 234.249
• Mol file: 923267-17-8.mol

Synonyms:(4,4-bis-hydroperoxy-cyclohexyl)-acetic acid ethyl ester

Chemical Property of (4,4-bis-hydroperoxy-cyclohexyl)-acetic acid ethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (4,4-bis-hydroperoxy-cyclohexyl)-acetic acid ethyl ester

There total 4 articles about (4,4-bis-hydroperoxy-cyclohexyl)-acetic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

ethyl 1,4-dioxaspiro[4.5]dec-8-ylacetate (62141-26-8) → (4,4-bis-hydroperoxy-cyclohexyl)-acetic acid ethyl ester (923267-17-8)

Guidance literature:

With dihydrogen peroxide; ortho-tungstic acid; In tetrahydrofuran; at 0 ℃; for 48h;

DOI:10.1039/b613565j

Reference yield:

ethyl 4-oxocyclohexaneacetate (58012-34-3) → (4,4-bis-hydroperoxy-cyclohexyl)-acetic acid ethyl ester (923267-17-8)

Guidance literature:

With formic acid; dihydrogen peroxide; In acetonitrile; at 0 - 20 ℃;

DOI:10.1002/anie.201001026

Reference yield:

cyclohexanedione monoethylene ketal (4746-97-8) → (4,4-bis-hydroperoxy-cyclohexyl)-acetic acid ethyl ester (923267-17-8)

Guidance literature:

Multi-step reaction with 3 steps

1: benzene / 24 h / Heating / reflux

2: hydrogen / palladium on activated carbon / 3 h

3: dihydrogen peroxide / ortho-tungstic acid / tetrahydrofuran; water / 48 h / 0 °C

With hydrogen; dihydrogen peroxide; palladium on activated carbon; ortho-tungstic acid; In tetrahydrofuran; water; benzene; 1: Wittig Reaction;

upstream raw materials:

ethyl 1,4-dioxaspiro[4.5]dec-8-ylacetate

ethyl 4-oxocyclohexaneacetate

cyclohexanedione monoethylene ketal

ethyl 1,4-dioxaspiro[4,5]dec-8-ylideneacetate

Downstream raw materials:

dispiro[cyclohexane-1,3'-[1,2,4,5]tetroxane-6',2''-tricyclo[3.3.1.1(3,7)]decan]-4-ylacetic acid