4-carboxy-6-(mercaptomethyl)-3,4,5,6-tetrahydropyrimidin-2(1H)-one

Base Information

Chemical Name:4-carboxy-6-(mercaptomethyl)-3,4,5,6-tetrahydropyrimidin-2(1H)-one
CAS No.:114132-84-2
Molecular Formula:C₆H₁₀N₂O₃S
Molecular Weight:190.223
Hs Code.:
Mol file:114132-84-2.mol

Synonyms:4-Pyrimidinecarboxylicacid, hexahydro-6-(mercaptomethyl)-2-oxo-, cis- (9CI); 4-Pyrimidinecarboxylicacid, hexahydro-6-(mercaptomethyl)-2-oxo-, cis-(?à)-

Suppliers and Price of 4-carboxy-6-(mercaptomethyl)-3,4,5,6-tetrahydropyrimidin-2(1H)-one

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 2 raw suppliers

Chemical Property of 4-carboxy-6-(mercaptomethyl)-3,4,5,6-tetrahydropyrimidin-2(1H)-one

Chemical Property:

Vapor Pressure:3.38E-14mmHg at 25°C
Boiling Point:564°Cat760mmHg
Flash Point:294.9°C
PSA：120.72000
Density:1.336g/cm³
LogP:-0.59030

Purity/Quality:: 99% ，98% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 4-carboxy-6-(mercaptomethyl)-3,4,5,6-tetrahydropyrimidin-2(1H)-one

There total 5 articles about 4-carboxy-6-(mercaptomethyl)-3,4,5,6-tetrahydropyrimidin-2(1H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

: 114132-82-0
cis-4-carbomethoxy-6-<(thioacetoxy)methyl>-3,4,5,6-tetrahydropyrimidin-2(1H)-one

: 114132-84-2
cis-4-carboxy-6-(mercaptomethyl)-3,4,5,6-tetrahydropyrimidin-2(1H)-one

Guidance literature:: With lithium hydroxide; In methanol;
DOI:10.1021/jm00402a018

Reference yield:

: 1421-04-1
2,4-diaminopentanedioic acid

: 114132-84-2
cis-4-carboxy-6-(mercaptomethyl)-3,4,5,6-tetrahydropyrimidin-2(1H)-one

Guidance literature:: Multi-step reaction with 5 steps

1: thionyl chloride / 24 h / 20 °C

2: 35 percent / Et₃N / dimethylformamide

3: 22 percent / BH₃*SMe₂ / acetonitrile / 1.5 h / 60 °C

4: 74 percent / triphenylphosphine, diisopropyl azodicarboxylate / tetrahydrofuran; dimethylformamide / 20 °C

5: 60 percent / aq. LiOH / methanol

With lithium hydroxide; thionyl chloride; di-isopropyl azodicarboxylate; dimethylsulfide borane complex; triethylamine; triphenylphosphine; In tetrahydrofuran; methanol; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1021/jm00402a018

Reference yield:

: 114132-78-4
cis-4-carbomethoxy-6-(hydroxymethyl)-3,4,5,6-tetrahydropyrimidin-2(1H)-one

: 114132-84-2
cis-4-carboxy-6-(mercaptomethyl)-3,4,5,6-tetrahydropyrimidin-2(1H)-one

Guidance literature:: Multi-step reaction with 2 steps

1: 74 percent / triphenylphosphine, diisopropyl azodicarboxylate / tetrahydrofuran; dimethylformamide / 20 °C

2: 60 percent / aq. LiOH / methanol

With lithium hydroxide; di-isopropyl azodicarboxylate; triphenylphosphine; In tetrahydrofuran; methanol; N,N-dimethyl-formamide;
DOI:10.1021/jm00402a018